Presentation of a novel method to estimate analog mean systemic filling pressure based on cardiac power.

Mean systemic filling pressure (MSFP) is a critical hemodynamic parameter for managing critically ill patients. Existing estimation methods either require invasive procedures or assume constant vascular resistances, limiting their applicability in clinical settings. We propose a novel method to estimate MSFP using cardiac power (CP), this method was developed in a cohort of 50 patients, validated in a different cohort of 50 patients, and tested in a historical cohort of 21 patients, showing a high correlation (r = 0.95 - 0.90) and agreement with Parkin analog Mean Systemic Filling Pressure (MSFPa) method. In brief MSFPe = (3.3*CP) + 2.2 + CVP. Our method provides an accurate, non-invasive bedside approach for estimating MSFP, facilitating hemodynamic assessment in critically ill patients and opening new research avenues on vascular resistance dynamics.