{"title":"邻苯二甲酸二（2-乙基己基）酯诱导脂质代谢紊乱的机制综述","authors":"Xiaoqi Fang, Tianrun Wang, Shihao Lou, Ying Qiao, Bo Zhang, Liting Zhou","doi":"10.1002/jat.4867","DOIUrl":null,"url":null,"abstract":"<p><p>Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer that can be absorbed by the human body through various pathways. Numerous studies have indicated the adverse effects of DEHP on lipid metabolism. Experimental and population studies have provided evidence for DEHP-induced lipid metabolism disorder. This review discusses the cellular pathophysiological changes leading to lipid metabolism disorders, including inflammation, apoptosis, autophagy, and oxidative stress. We also summarize the key molecules and signaling pathways involved in the lipid metabolism disorder induced by DEHP. Additionally, multiple omics such as metabolomics, transcriptomics, and epigenetics are discussed in this review. Furthermore, this article provides some directions for future research about the mechanisms of lipid metabolism disorders caused by DEHP, aiming to offer more detailed and reliable theoretical evidence for the prevention and treatment of lipid metabolism disorders.</p>","PeriodicalId":15242,"journal":{"name":"Journal of Applied Toxicology","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mechanisms of di (2-Ethylhexyl) Phthalate-Induced Lipid Metabolism Disorders: A Review.\",\"authors\":\"Xiaoqi Fang, Tianrun Wang, Shihao Lou, Ying Qiao, Bo Zhang, Liting Zhou\",\"doi\":\"10.1002/jat.4867\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer that can be absorbed by the human body through various pathways. Numerous studies have indicated the adverse effects of DEHP on lipid metabolism. Experimental and population studies have provided evidence for DEHP-induced lipid metabolism disorder. This review discusses the cellular pathophysiological changes leading to lipid metabolism disorders, including inflammation, apoptosis, autophagy, and oxidative stress. We also summarize the key molecules and signaling pathways involved in the lipid metabolism disorder induced by DEHP. Additionally, multiple omics such as metabolomics, transcriptomics, and epigenetics are discussed in this review. Furthermore, this article provides some directions for future research about the mechanisms of lipid metabolism disorders caused by DEHP, aiming to offer more detailed and reliable theoretical evidence for the prevention and treatment of lipid metabolism disorders.</p>\",\"PeriodicalId\":15242,\"journal\":{\"name\":\"Journal of Applied Toxicology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Applied Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jat.4867\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jat.4867","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"TOXICOLOGY","Score":null,"Total":0}
Mechanisms of di (2-Ethylhexyl) Phthalate-Induced Lipid Metabolism Disorders: A Review.
Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer that can be absorbed by the human body through various pathways. Numerous studies have indicated the adverse effects of DEHP on lipid metabolism. Experimental and population studies have provided evidence for DEHP-induced lipid metabolism disorder. This review discusses the cellular pathophysiological changes leading to lipid metabolism disorders, including inflammation, apoptosis, autophagy, and oxidative stress. We also summarize the key molecules and signaling pathways involved in the lipid metabolism disorder induced by DEHP. Additionally, multiple omics such as metabolomics, transcriptomics, and epigenetics are discussed in this review. Furthermore, this article provides some directions for future research about the mechanisms of lipid metabolism disorders caused by DEHP, aiming to offer more detailed and reliable theoretical evidence for the prevention and treatment of lipid metabolism disorders.
期刊介绍：
Journal of Applied Toxicology publishes peer-reviewed original reviews and hypothesis-driven research articles on mechanistic, fundamental and applied research relating to the toxicity of drugs and chemicals at the molecular, cellular, tissue, target organ and whole body level in vivo (by all relevant routes of exposure) and in vitro / ex vivo. All aspects of toxicology are covered (including but not limited to nanotoxicology, genomics and proteomics, teratogenesis, carcinogenesis, mutagenesis, reproductive and endocrine toxicology, toxicopathology, target organ toxicity, systems toxicity (eg immunotoxicity), neurobehavioral toxicology, mechanistic studies, biochemical and molecular toxicology, novel biomarkers, pharmacokinetics/PBPK, risk assessment and environmental health studies) and emphasis is given to papers of clear application to human health, and/or advance mechanistic understanding and/or provide significant contributions and impact to their field.
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