在典型21-羟化酶先天性肾上腺增生的年轻患者中，糖皮质激素和矿化皮质激素的替代应该如何优化？

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Internal Medicine Journal Pub Date : 2025-07-29 DOI:10.1111/imj.70174

Stephanie Teasdale, Kriti Joshi, Tony Huynh, Louise S. Conwell

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引用次数: 0

摘要

本文旨在提供一种简单的临床方法来理解和管理年轻人和成人继发于21-羟化酶缺乏症（21OHD）的经典先天性肾上腺增生患者的类固醇补充。它旨在克服导致这些患者糖皮质激素过量的临床惰性，特别是在成年内分泌学家以“新鲜的眼光”遇到21OHD患者时。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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How should glucocorticoid and mineralocorticoid replacement be optimised in a young patient with classic 21-hydroxylase congenital adrenal hyperplasia?

This article aims to provide a simple clinical approach to understanding and managing steroid supplementation in young adults and adult patients with classical congenital adrenal hyperplasia secondary to 21-hydroxylase deficiency (21OHD). It aims to overcome the clinical inertia that leads to glucocorticoid excess in these patients, particularly addressing the adult endocrinologist at the transition when they meet the patient with 21OHD with ‘fresh eyes’.

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来源期刊

Internal Medicine Journal 医学-医学：内科

CiteScore

3.50

自引率

4.80%

发文量

600

审稿时长

3-6 weeks

期刊介绍： The Internal Medicine Journal is the official journal of the Adult Medicine Division of The Royal Australasian College of Physicians (RACP). Its purpose is to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. The Journal also has a major role in continuing medical education and publishes review articles relevant to physician education.