{"title":"外泌体miR17-92a簇和靶基因与乳腺癌风险的关系","authors":"Ambreen Parvaiz, Azhar Mehmood, Muhammad Saeed, Mahmood Akhtar Kayani, Ishrat Mahjabeen","doi":"10.1080/14796694.2025.2539627","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to explore the roles of exosomal microRNAs (miR-17, miR-19b, and miR-92a) and two target genes (PTEN and TGFβR2) in breast cancer risk.</p><p><strong>Methods: </strong>Expression analysis was performed using real-time PCR in a study cohort of 500 patients and 500 age- and sex-matched healthy controls.</p><p><strong>Results: </strong>The selected miRNAs (miR-17, p < 0.01; miR-19b, p < 0.01; miR-92a, p < 0.01) and TGFβR2 (p < 0.01) revealed an upregulated expression pattern, whereas downregulation of PTEN (p < 0.05) was observed in cancer patients compared to controls. A significant upregulated expression of miR-17, miR-92a, and TGFβR2 was observed in advanced clinical stages, advanced T-stage, advanced N-stage, and advanced M-stage in breast cancer patients.</p><p><strong>Conclusions: </strong>These findings demonstrate the oncogenic potential of the selected miRNAs, contributing to breast carcinogenesis. Further analysis showed an association between the expression deregulation of the selected molecules and increased cell proliferation and metastasis. miR-17 and TGFβR2 showed good diagnostic potential with AUCs of 0.708 and 0.909, respectively.</p>","PeriodicalId":12672,"journal":{"name":"Future oncology","volume":" ","pages":"2731-2746"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407647/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of exosomal miR17-92a cluster and target genes with breast cancer risk.\",\"authors\":\"Ambreen Parvaiz, Azhar Mehmood, Muhammad Saeed, Mahmood Akhtar Kayani, Ishrat Mahjabeen\",\"doi\":\"10.1080/14796694.2025.2539627\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The present study aimed to explore the roles of exosomal microRNAs (miR-17, miR-19b, and miR-92a) and two target genes (PTEN and TGFβR2) in breast cancer risk.</p><p><strong>Methods: </strong>Expression analysis was performed using real-time PCR in a study cohort of 500 patients and 500 age- and sex-matched healthy controls.</p><p><strong>Results: </strong>The selected miRNAs (miR-17, p < 0.01; miR-19b, p < 0.01; miR-92a, p < 0.01) and TGFβR2 (p < 0.01) revealed an upregulated expression pattern, whereas downregulation of PTEN (p < 0.05) was observed in cancer patients compared to controls. A significant upregulated expression of miR-17, miR-92a, and TGFβR2 was observed in advanced clinical stages, advanced T-stage, advanced N-stage, and advanced M-stage in breast cancer patients.</p><p><strong>Conclusions: </strong>These findings demonstrate the oncogenic potential of the selected miRNAs, contributing to breast carcinogenesis. Further analysis showed an association between the expression deregulation of the selected molecules and increased cell proliferation and metastasis. miR-17 and TGFβR2 showed good diagnostic potential with AUCs of 0.708 and 0.909, respectively.</p>\",\"PeriodicalId\":12672,\"journal\":{\"name\":\"Future oncology\",\"volume\":\" \",\"pages\":\"2731-2746\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407647/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/14796694.2025.2539627\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14796694.2025.2539627","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/29 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Association of exosomal miR17-92a cluster and target genes with breast cancer risk.
Background: The present study aimed to explore the roles of exosomal microRNAs (miR-17, miR-19b, and miR-92a) and two target genes (PTEN and TGFβR2) in breast cancer risk.
Methods: Expression analysis was performed using real-time PCR in a study cohort of 500 patients and 500 age- and sex-matched healthy controls.
Results: The selected miRNAs (miR-17, p < 0.01; miR-19b, p < 0.01; miR-92a, p < 0.01) and TGFβR2 (p < 0.01) revealed an upregulated expression pattern, whereas downregulation of PTEN (p < 0.05) was observed in cancer patients compared to controls. A significant upregulated expression of miR-17, miR-92a, and TGFβR2 was observed in advanced clinical stages, advanced T-stage, advanced N-stage, and advanced M-stage in breast cancer patients.
Conclusions: These findings demonstrate the oncogenic potential of the selected miRNAs, contributing to breast carcinogenesis. Further analysis showed an association between the expression deregulation of the selected molecules and increased cell proliferation and metastasis. miR-17 and TGFβR2 showed good diagnostic potential with AUCs of 0.708 and 0.909, respectively.
期刊介绍：
Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community.
The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.
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