{"title":"MeA - Tac1神经回路介导小鼠的焦虑样行为。","authors":"Yao Wang, Jiu-Ye Qiao, Mei-Hui Yue, Xin-Yue Lv, Si-Ran Wang, Qian-Qian Yang, Han-Yun Kang, Hua-Li Yu, Xiao-Xiao He, Xiao-Juan Zhu, Zi-Xuan He","doi":"10.1038/s44319-025-00528-z","DOIUrl":null,"url":null,"abstract":"<p><p>Anxiety is an emotion characterized by worried thoughts and feelings of unease, often accompanied by physical symptoms such as sweating and dizziness. Unlike other negative emotions, the neural circuits underlying anxiety are not well understood. Here we report that Tachykinin Precursor 1 (Tac1)-expressing neurons in the medial amygdala (MeA) respond to the transition from high anxiety to low anxiety states. The MeATac1 neurons regulate anxiety-like behaviors in mice bidirectionally. We also show that GABAergic neurons in the ventral tegmental area (VTA)<sup>GABA</sup>→MeA<sup>Tac1</sup>→ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) circuit contribute to anxiety-like behavior in mice. Our findings reveal a circuit of Tac1 neurons in the MeA that mediates anxiety-like behaviors in mice.</p>","PeriodicalId":11541,"journal":{"name":"EMBO Reports","volume":" ","pages":"4340-4363"},"PeriodicalIF":6.2000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12420787/pdf/","citationCount":"0","resultStr":"{\"title\":\"A MeA Tac1 neural circuit mediates anxiety-like behaviors in mice.\",\"authors\":\"Yao Wang, Jiu-Ye Qiao, Mei-Hui Yue, Xin-Yue Lv, Si-Ran Wang, Qian-Qian Yang, Han-Yun Kang, Hua-Li Yu, Xiao-Xiao He, Xiao-Juan Zhu, Zi-Xuan He\",\"doi\":\"10.1038/s44319-025-00528-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Anxiety is an emotion characterized by worried thoughts and feelings of unease, often accompanied by physical symptoms such as sweating and dizziness. Unlike other negative emotions, the neural circuits underlying anxiety are not well understood. Here we report that Tachykinin Precursor 1 (Tac1)-expressing neurons in the medial amygdala (MeA) respond to the transition from high anxiety to low anxiety states. The MeATac1 neurons regulate anxiety-like behaviors in mice bidirectionally. We also show that GABAergic neurons in the ventral tegmental area (VTA)<sup>GABA</sup>→MeA<sup>Tac1</sup>→ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) circuit contribute to anxiety-like behavior in mice. Our findings reveal a circuit of Tac1 neurons in the MeA that mediates anxiety-like behaviors in mice.</p>\",\"PeriodicalId\":11541,\"journal\":{\"name\":\"EMBO Reports\",\"volume\":\" \",\"pages\":\"4340-4363\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12420787/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EMBO Reports\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1038/s44319-025-00528-z\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EMBO Reports","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s44319-025-00528-z","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/28 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
A MeA Tac1 neural circuit mediates anxiety-like behaviors in mice.
Anxiety is an emotion characterized by worried thoughts and feelings of unease, often accompanied by physical symptoms such as sweating and dizziness. Unlike other negative emotions, the neural circuits underlying anxiety are not well understood. Here we report that Tachykinin Precursor 1 (Tac1)-expressing neurons in the medial amygdala (MeA) respond to the transition from high anxiety to low anxiety states. The MeATac1 neurons regulate anxiety-like behaviors in mice bidirectionally. We also show that GABAergic neurons in the ventral tegmental area (VTA)GABA→MeATac1→ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) circuit contribute to anxiety-like behavior in mice. Our findings reveal a circuit of Tac1 neurons in the MeA that mediates anxiety-like behaviors in mice.
期刊介绍：
EMBO Reports is a scientific journal that specializes in publishing research articles in the fields of molecular biology, cell biology, and developmental biology. The journal is known for its commitment to publishing high-quality, impactful research that provides novel physiological and functional insights. These insights are expected to be supported by robust evidence, with independent lines of inquiry validating the findings.
The journal's scope includes both long and short-format papers, catering to different types of research contributions. It values studies that:
Communicate major findings: Articles that report significant discoveries or advancements in the understanding of biological processes at the molecular, cellular, and developmental levels.
Confirm important findings: Research that validates or supports existing knowledge in the field, reinforcing the reliability of previous studies.
Refute prominent claims: Studies that challenge or disprove widely accepted ideas or hypotheses in the biosciences, contributing to the correction and evolution of scientific understanding.
Present null data: Papers that report negative results or findings that do not support a particular hypothesis, which are crucial for the scientific process as they help to refine or redirect research efforts.
EMBO Reports is dedicated to maintaining high standards of scientific rigor and integrity, ensuring that the research it publishes contributes meaningfully to the advancement of knowledge in the life sciences. By covering a broad spectrum of topics and encouraging the publication of both positive and negative results, the journal plays a vital role in promoting a comprehensive and balanced view of scientific inquiry.
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