纳米铁氧体-壳聚糖-姜黄素纳米颗粒对十醇诺龙引起的雄性大鼠肾毒性、炎症和氧化应激的改善和治疗作用。

IF 2.1 4区 医学 Q3 TOXICOLOGY
Toxicology Research Pub Date : 2025-07-24 eCollection Date: 2025-08-01 DOI:10.1093/toxres/tfaf103
Ehab Tousson, Afaf El Atrash, Somia Zaki, Marwa Negm
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引用次数: 0

摘要

“合成代谢雄激素类固醇”(AASs)一词是指一类类似天然睾酮的人造物质。最常被滥用的雄激素癸酸诺龙(ND)被视为一个公共卫生问题,需要立即采取行动,提高公众对AAS使用的毒理学结果的认识。本研究旨在探讨纳米铁氧体-壳聚糖-姜黄素纳米颗粒(NF-CH-CurNPs)对ND诱导的雄性大鼠肾毒性、增殖、炎症和氧化应激的治疗作用。48只成年雄性大鼠随机分为6组[第一组为对照组;第二组为CurNPs,给予CurNPs (50 mg/kg BW/2 day),连续2周;第三组为NF-CH-CurNPs组,连续2周给予NF-CH-CurNPs (24 mg/Kg BW/2 day);第4组为ND,连续4周给予ND (25 mg/Kg BW/周);第5组为ND + CurNPs,先予ND治疗4周,再予CurNPs治疗2周;第6组为ND + NF-CH-CurNPs,先予ND治疗4周,再予NF-CH-CurNPs治疗2周。与对照组相比,ND给药后血清尿素、肌酐、肾损害、MDA、PCNA、TNFα显著升高,钠、钾离子、过氧化氢酶、SOD、GSH显著减少。相反,用CurNPs或/和NF-CH-CurNPs治疗ND可显著增强所研究的参数、肾脏结构和功能、氧化应激、PCNA和TNFα表达,其中NF-CH-CurNPs治疗效果最好,可能清除自由基,与ND相比具有更有价值的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ameliorating and therapeutic impact of nano ferrite-chitosan-curcumin nanoparticles against nandrolone decanote induced renal toxicity, inflammation, and oxidative stress in male rats.

The term ``anabolic-androgenic steroids'' (AASs) refers to a class of artificial substances that resemble the natural testosterone. The most often misused androgen, nandrolone decanoate (ND), is regarded as a public health concern that needs immediate action to raise public awareness of toxicology results on AAS usage. This study designed to investigate the therapeutics effect of nano ferrite-chitosan-curcumin nanoparticles (NF-CH-CurNPs) against ND induced renal toxicity, proliferation, inflammation, and oxidative stress in male rats. A total of 48 adult male rats were assigned randomly to 6 groups [1st group was control; 2nd group was CurNPs where rats received CurNPs (50 mg/kg BW/2 day) for two wk; 3rd group was NF-CH-CurNPs where rats received NF-CH-CurNPs (24 mg/Kg BW/2 day) for 2 wk.; 4th group was ND where rats received ND (25 mg/Kg BW/wk) for four wk; 5th group was ND + CurNPs in which rats received ND for 4 wk then treated with CurNPs for another 2 wk; 6th group was ND + NF-CH-CurNPs where rats received ND for 4 wk then treated with NF-CH-CurNPs for another 2 wk]. A significant elevation in serum Urea, creatinine, kidney damage, MDA, PCNA, TNFα and a significant depletion in sodium, potassium ions, catalase, SOD, GSH after ND administration as compared to control. On the contrary, treatment of ND with CurNPs or/and NF-CH-CurNPs induced significant enhancements of the studied parameters, kidney structure and functions, oxidative stress, PCNA and TNFα expressions with best results for the treatments with NF-CH-CurNPs that may possibly scavenge free radicals creating valuable effects in contrast to ND.

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来源期刊
Toxicology Research
Toxicology Research TOXICOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
82
期刊介绍: A multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
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