{"title":"具有保护意识的年龄结构HIV/AIDS传播模型稳定性分析及最优干预设计","authors":"Yaping Wang, Lin Hu, Lin-Fei Nie","doi":"10.1016/j.matcom.2025.07.036","DOIUrl":null,"url":null,"abstract":"<div><div>In keeping with the age heterogeneity observed in HIV/AIDS transmission, a novel age-structured model incorporating protective consciousness is introduced. Our research delves into the existence and stability of steady states in relation to basic reproduction number <span><math><msub><mrow><mi>ℛ</mi></mrow><mrow><mn>0</mn></mrow></msub></math></span> (or <span><math><msub><mrow><mover><mrow><mi>ℛ</mi></mrow><mrow><mo>˜</mo></mrow></mover></mrow><mrow><mn>0</mn></mrow></msub></math></span>). Specifically, we demonstrate that when the basic reproduction number is less than 1, a globally stable disease-free steady state <span><math><msup><mrow><mi>E</mi></mrow><mrow><mn>0</mn></mrow></msup></math></span> exists, this implies that the disease will disappear. In scenarios where disease-induced death is absent, the endemic steady state <span><math><msup><mrow><mi>E</mi></mrow><mrow><mo>∗</mo></mrow></msup></math></span> becomes the sole existing steady state and exhibits local asymptotic stability for the basic reproduction number is more than 1, thereby perpetuating the disease. To further enhance the applicability of our model, we incorporate control functions such as physical distancing, educational campaigns, and treatment and then formulate an optimal control problem and rigorously prove the existence and uniqueness of optimal control solution. This approach provides a robust theoretical foundation for designing effective intervention strategies. Numerical simulations are conducted to illustrate the core findings of our study, indicating the critical role of age variability in the dissemination dynamics of HIV/AIDS. Notably, our results suggest that targeting educational interventions to achieve self-protection awareness toward younger populations yields significantly greater effectiveness compared to implementing uniform strategies across all age groups. This insight underscores the importance of age-specific approaches in optimizing resource allocation and maximizing public health impact.</div></div>","PeriodicalId":49856,"journal":{"name":"Mathematics and Computers in Simulation","volume":"240 ","pages":"Pages 494-519"},"PeriodicalIF":4.4000,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Stability analysis and optimal intervention design for age-structured HIV/AIDS transmission model with protective consciousness\",\"authors\":\"Yaping Wang, Lin Hu, Lin-Fei Nie\",\"doi\":\"10.1016/j.matcom.2025.07.036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>In keeping with the age heterogeneity observed in HIV/AIDS transmission, a novel age-structured model incorporating protective consciousness is introduced. Our research delves into the existence and stability of steady states in relation to basic reproduction number <span><math><msub><mrow><mi>ℛ</mi></mrow><mrow><mn>0</mn></mrow></msub></math></span> (or <span><math><msub><mrow><mover><mrow><mi>ℛ</mi></mrow><mrow><mo>˜</mo></mrow></mover></mrow><mrow><mn>0</mn></mrow></msub></math></span>). Specifically, we demonstrate that when the basic reproduction number is less than 1, a globally stable disease-free steady state <span><math><msup><mrow><mi>E</mi></mrow><mrow><mn>0</mn></mrow></msup></math></span> exists, this implies that the disease will disappear. In scenarios where disease-induced death is absent, the endemic steady state <span><math><msup><mrow><mi>E</mi></mrow><mrow><mo>∗</mo></mrow></msup></math></span> becomes the sole existing steady state and exhibits local asymptotic stability for the basic reproduction number is more than 1, thereby perpetuating the disease. To further enhance the applicability of our model, we incorporate control functions such as physical distancing, educational campaigns, and treatment and then formulate an optimal control problem and rigorously prove the existence and uniqueness of optimal control solution. This approach provides a robust theoretical foundation for designing effective intervention strategies. Numerical simulations are conducted to illustrate the core findings of our study, indicating the critical role of age variability in the dissemination dynamics of HIV/AIDS. Notably, our results suggest that targeting educational interventions to achieve self-protection awareness toward younger populations yields significantly greater effectiveness compared to implementing uniform strategies across all age groups. This insight underscores the importance of age-specific approaches in optimizing resource allocation and maximizing public health impact.</div></div>\",\"PeriodicalId\":49856,\"journal\":{\"name\":\"Mathematics and Computers in Simulation\",\"volume\":\"240 \",\"pages\":\"Pages 494-519\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2025-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mathematics and Computers in Simulation\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0378475425003015\",\"RegionNum\":2,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mathematics and Computers in Simulation","FirstCategoryId":"100","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378475425003015","RegionNum":2,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
Stability analysis and optimal intervention design for age-structured HIV/AIDS transmission model with protective consciousness
In keeping with the age heterogeneity observed in HIV/AIDS transmission, a novel age-structured model incorporating protective consciousness is introduced. Our research delves into the existence and stability of steady states in relation to basic reproduction number (or ). Specifically, we demonstrate that when the basic reproduction number is less than 1, a globally stable disease-free steady state exists, this implies that the disease will disappear. In scenarios where disease-induced death is absent, the endemic steady state becomes the sole existing steady state and exhibits local asymptotic stability for the basic reproduction number is more than 1, thereby perpetuating the disease. To further enhance the applicability of our model, we incorporate control functions such as physical distancing, educational campaigns, and treatment and then formulate an optimal control problem and rigorously prove the existence and uniqueness of optimal control solution. This approach provides a robust theoretical foundation for designing effective intervention strategies. Numerical simulations are conducted to illustrate the core findings of our study, indicating the critical role of age variability in the dissemination dynamics of HIV/AIDS. Notably, our results suggest that targeting educational interventions to achieve self-protection awareness toward younger populations yields significantly greater effectiveness compared to implementing uniform strategies across all age groups. This insight underscores the importance of age-specific approaches in optimizing resource allocation and maximizing public health impact.
期刊介绍:
The aim of the journal is to provide an international forum for the dissemination of up-to-date information in the fields of the mathematics and computers, in particular (but not exclusively) as they apply to the dynamics of systems, their simulation and scientific computation in general. Published material ranges from short, concise research papers to more general tutorial articles.
Mathematics and Computers in Simulation, published monthly, is the official organ of IMACS, the International Association for Mathematics and Computers in Simulation (Formerly AICA). This Association, founded in 1955 and legally incorporated in 1956 is a member of FIACC (the Five International Associations Coordinating Committee), together with IFIP, IFAV, IFORS and IMEKO.
Topics covered by the journal include mathematical tools in:
•The foundations of systems modelling
•Numerical analysis and the development of algorithms for simulation
They also include considerations about computer hardware for simulation and about special software and compilers.
The journal also publishes articles concerned with specific applications of modelling and simulation in science and engineering, with relevant applied mathematics, the general philosophy of systems simulation, and their impact on disciplinary and interdisciplinary research.
The journal includes a Book Review section -- and a "News on IMACS" section that contains a Calendar of future Conferences/Events and other information about the Association.