吡啶- n -氧化物催化n -酰化动力学分解亚砜亚胺。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-27 DOI:10.1021/acs.orglett.5c02496

Jun-Yu Liu, Ning Li, Ming-Sheng Xie* and Hai-Ming Guo*,

引用次数: 0

摘要

以手性4-芳基吡啶- n -氧化物为催化剂，对亚砜亚胺进行了高效的不对称n -酰化动力学拆分。以3,5-二（三氟甲基）苯甲酰氯为酰基转移剂，回收的亚砜亚胺和n -酰化亚砜亚胺均表现出良好至优异的效果，其因数高达320。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pyridine-N-oxide-Catalyzed N-Acylative Kinetic Resolution of Sulfoximines

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Pyridine-N-oxide-Catalyzed N-Acylative Kinetic Resolution of Sulfoximines

An efficient asymmetric N-acylative kinetic resolution of sulfoximines using chiral 4-arylpyridine-N-oxide as the catalyst was reported. Using 3,5-bis(trifluoromethyl)benzoyl chloride as the acyl transfer agent, both the recovered sulfoximines and the N-acylative sulfoximines exhibited good to excellent results, with s factors of up to 320.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.