Unique ultrasound contrast agent-coated needle biopsy technique in oncology patients.

Biopsy plays a pivotal role in the diagnosis and management of soft-tissue masses. Conventional ultrasound-guided biopsies offer advantages such as real-time imaging and avoidance of radiation exposure, yet they present challenges in precise targeting, operator experience, and complications. In response to these challenges, a novel technique, ultrasound contrast agent coated needle biopsy, has emerged, harnessing the power of microbubble contrast agents to enhance imaging. This technique was applied in five cases to address the difficulties encountered during routine ultrasound-guided biopsies. These cases encompassed a diverse range of clinical scenarios, including soft tissue tumors, bone metastasis, and post-treatment changes. Challenges included obscured needle visualization due to various factors such as rib shadows, fragmented bony fragments, and background fibrosis.