Menayit Tamrat Dresse, Pamela C L Ferreira, Akshay Prasadan, Jihui L Diaz, Xuemei Zeng, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, M Ilyas Kamboh, Ann D Cohen, Tharick A Pascoal, Mary Ganguli, Beth E Snitz, C Elizabeth Shaaban, Thomas K Karikari
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Plasma p-tau181 and p-tau217 showed significant associations with tau-PET status (AOR: 1.50 and 22.24, respectively (p-values < 0.05), with comparable classification accuracies for tau-PET status (AUC = 0.74 and 0.70, respectively). Only plasma NfL showed significant association with neurodegeneration based on cortical thickness (AOR = 1.09, p-value < 0.05).</p><p><strong>Conclusion: </strong>Our findings highlight the potential of plasma p-tau217 as a biomarker for brain Aβ and tau pathophysiology, p-tau181 for tau abnormalities, and NfL for neurodegeneration in the community.</p>","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":"17 1","pages":"173"},"PeriodicalIF":7.6000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291478/pdf/","citationCount":"0","resultStr":"{\"title\":\"Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort.\",\"authors\":\"Menayit Tamrat Dresse, Pamela C L Ferreira, Akshay Prasadan, Jihui L Diaz, Xuemei Zeng, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, M Ilyas Kamboh, Ann D Cohen, Tharick A Pascoal, Mary Ganguli, Beth E Snitz, C Elizabeth Shaaban, Thomas K Karikari\",\"doi\":\"10.1186/s13195-025-01803-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Using the ATN framework, we evaluated the potential of plasma biomarkers to identify abnormal brain amyloid-beta (Aβ) positron emission tomography (PET), tau-PET and neurodegeneration in a socioeconomically disadvantaged population-based cohort.</p><p><strong>Methods: </strong>Community-dwelling dementia-free (n = 113, including 102 (91%) cognitively normal) participants underwent ATN neuroimaging and plasma biomarker assessments.</p><p><strong>Results: </strong>Plasma Aβ42/Aβ40, p-tau181, and p-tau217 showed significant associations with Aβ-PET status, (adjusted odds ratio [AOR] of 1.74*10<sup>-24</sup>, 1.47, and 3.43*10<sup>3</sup>, respectively (p-values < 0.05), with p-tau217 demonstrating the highest classification accuracy for Aβ-PET status (AUC = 0.94). 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引用次数: 0
摘要
使用ATN框架，我们评估了血浆生物标志物在以社会经济弱势人群为基础的队列中识别异常脑淀粉样蛋白- β (a β)正电子发射断层扫描（PET）、tau-PET和神经退行性变的潜力。方法：社区居住无痴呆（n = 113，包括102（91%）认知正常）参与者接受ATN神经成像和血浆生物标志物评估。结果：血浆a - β42/ a - β40、p-tau181和p-tau217与a - β- pet状态显著相关，调整后的优势比分别为1.74*10-24、1.47和3.43*103 （p值）。结论：我们的研究结果突出了血浆p-tau217作为脑a β和tau病理生理的生物标志物，p-tau181用于tau异常，NfL用于社区神经变性的潜力。
Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort.
Introduction: Using the ATN framework, we evaluated the potential of plasma biomarkers to identify abnormal brain amyloid-beta (Aβ) positron emission tomography (PET), tau-PET and neurodegeneration in a socioeconomically disadvantaged population-based cohort.
Methods: Community-dwelling dementia-free (n = 113, including 102 (91%) cognitively normal) participants underwent ATN neuroimaging and plasma biomarker assessments.
Results: Plasma Aβ42/Aβ40, p-tau181, and p-tau217 showed significant associations with Aβ-PET status, (adjusted odds ratio [AOR] of 1.74*10-24, 1.47, and 3.43*103, respectively (p-values < 0.05), with p-tau217 demonstrating the highest classification accuracy for Aβ-PET status (AUC = 0.94). Plasma p-tau181 and p-tau217 showed significant associations with tau-PET status (AOR: 1.50 and 22.24, respectively (p-values < 0.05), with comparable classification accuracies for tau-PET status (AUC = 0.74 and 0.70, respectively). Only plasma NfL showed significant association with neurodegeneration based on cortical thickness (AOR = 1.09, p-value < 0.05).
Conclusion: Our findings highlight the potential of plasma p-tau217 as a biomarker for brain Aβ and tau pathophysiology, p-tau181 for tau abnormalities, and NfL for neurodegeneration in the community.
期刊介绍：
Alzheimer's Research & Therapy is an international peer-reviewed journal that focuses on translational research into Alzheimer's disease and other neurodegenerative diseases. It publishes open-access basic research, clinical trials, drug discovery and development studies, and epidemiologic studies. The journal also includes reviews, viewpoints, commentaries, debates, and reports. All articles published in Alzheimer's Research & Therapy are included in several reputable databases such as CAS, Current contents, DOAJ, Embase, Journal Citation Reports/Science Edition, MEDLINE, PubMed, PubMed Central, Science Citation Index Expanded (Web of Science) and Scopus.
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