Silke Kern, Tobias Skillbäck, Henrik Zetterberg, Anna Dittrich, Felicia Ahlner, Anna Zettergren, Margda Waern, Nazib M Seidu, Ulf Andreasson, Kaj Blennow, Ingmar Skoog
{"title":"以70岁人群为基础的阿尔茨海默病的酒精摄入量和脑脊液生物标志物","authors":"Silke Kern, Tobias Skillbäck, Henrik Zetterberg, Anna Dittrich, Felicia Ahlner, Anna Zettergren, Margda Waern, Nazib M Seidu, Ulf Andreasson, Kaj Blennow, Ingmar Skoog","doi":"10.1186/s13195-025-01819-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>It is largely unknown how alcohol use affects the risk of Alzheimer`s disease (AD). Therefore, studies on the influence of alcohol use on cerebrospinal fluid (CSF) biomarkers for the earliest preclinical phase of AD are needed.</p><p><strong>Methods: </strong>This was a cross-sectional cohort study. The sample (n = 301) was derived from the 2014-2016 examinations of the Gothenburg H70 Birth Cohort Studies. The study cohort consisted of 301 70-year-old women and men, where of 246 cognitively unimpaired and 55 with mild cognitive deficits. Information on alcohol consumption (g/week and type of alcohol) was collected and CSF amyloid-β<sub>1-42</sub> (Aβ42), total-tau (T-tau), tau phosphorylated at threonine 181 (P-tau181), neurofilament light protein (NfL) and neurogranin (Ng) were measured. We tested the association between the CSF biomarkers and alcohol consumption types using correlation and linear regression, adjusting for possible confounders when necessary according to the performed sensitivity analysis.</p><p><strong>Results: </strong>There were no correlations between weekly alcohol consumption and any of the CSF markers studied in the total sample of cognitively unimpaired participants (n = 246). After adjustments for multiplicity with FDR, there was an association between white wine and Ng in women with CDR = 0 (β:0.254, CI: ( 0.069: 0.439), p = 0.0076, FDR = 0.0455). Interaction analysis between female sex and red wine intake was a significant predictor of high Ng levels (β:0.410, CI: ( 0.099: 0.721), p = 0.0100, FDR = 0.0500). There were no correlations between consumption of specific types of alcohol (spirits, white wine, red wine, fortified wine, and beer) and any of the biomarkers studied in the total sample of cognitively unimpaired participants.</p><p><strong>Conclusions: </strong>Our findings indicate that higher alcohol use in older cognitively unimpaired women correlates with a biomarker of synaptic dysfunction in AD, which is an important observation in a time when alcohol use is increasing among women.</p>","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":"17 1","pages":"175"},"PeriodicalIF":7.6000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291311/pdf/","citationCount":"0","resultStr":"{\"title\":\"Alcohol consumption and cerebrospinal fluid biomarkers for preclinical alzheimer's disease in a population-based sample of 70-year-olds.\",\"authors\":\"Silke Kern, Tobias Skillbäck, Henrik Zetterberg, Anna Dittrich, Felicia Ahlner, Anna Zettergren, Margda Waern, Nazib M Seidu, Ulf Andreasson, Kaj Blennow, Ingmar Skoog\",\"doi\":\"10.1186/s13195-025-01819-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>It is largely unknown how alcohol use affects the risk of Alzheimer`s disease (AD). Therefore, studies on the influence of alcohol use on cerebrospinal fluid (CSF) biomarkers for the earliest preclinical phase of AD are needed.</p><p><strong>Methods: </strong>This was a cross-sectional cohort study. The sample (n = 301) was derived from the 2014-2016 examinations of the Gothenburg H70 Birth Cohort Studies. The study cohort consisted of 301 70-year-old women and men, where of 246 cognitively unimpaired and 55 with mild cognitive deficits. Information on alcohol consumption (g/week and type of alcohol) was collected and CSF amyloid-β<sub>1-42</sub> (Aβ42), total-tau (T-tau), tau phosphorylated at threonine 181 (P-tau181), neurofilament light protein (NfL) and neurogranin (Ng) were measured. We tested the association between the CSF biomarkers and alcohol consumption types using correlation and linear regression, adjusting for possible confounders when necessary according to the performed sensitivity analysis.</p><p><strong>Results: </strong>There were no correlations between weekly alcohol consumption and any of the CSF markers studied in the total sample of cognitively unimpaired participants (n = 246). After adjustments for multiplicity with FDR, there was an association between white wine and Ng in women with CDR = 0 (β:0.254, CI: ( 0.069: 0.439), p = 0.0076, FDR = 0.0455). Interaction analysis between female sex and red wine intake was a significant predictor of high Ng levels (β:0.410, CI: ( 0.099: 0.721), p = 0.0100, FDR = 0.0500). There were no correlations between consumption of specific types of alcohol (spirits, white wine, red wine, fortified wine, and beer) and any of the biomarkers studied in the total sample of cognitively unimpaired participants.</p><p><strong>Conclusions: </strong>Our findings indicate that higher alcohol use in older cognitively unimpaired women correlates with a biomarker of synaptic dysfunction in AD, which is an important observation in a time when alcohol use is increasing among women.</p>\",\"PeriodicalId\":7516,\"journal\":{\"name\":\"Alzheimer's Research & Therapy\",\"volume\":\"17 1\",\"pages\":\"175\"},\"PeriodicalIF\":7.6000,\"publicationDate\":\"2025-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291311/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's Research & Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s13195-025-01819-2\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's Research & Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13195-025-01819-2","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Alcohol consumption and cerebrospinal fluid biomarkers for preclinical alzheimer's disease in a population-based sample of 70-year-olds.
Background: It is largely unknown how alcohol use affects the risk of Alzheimer`s disease (AD). Therefore, studies on the influence of alcohol use on cerebrospinal fluid (CSF) biomarkers for the earliest preclinical phase of AD are needed.
Methods: This was a cross-sectional cohort study. The sample (n = 301) was derived from the 2014-2016 examinations of the Gothenburg H70 Birth Cohort Studies. The study cohort consisted of 301 70-year-old women and men, where of 246 cognitively unimpaired and 55 with mild cognitive deficits. Information on alcohol consumption (g/week and type of alcohol) was collected and CSF amyloid-β1-42 (Aβ42), total-tau (T-tau), tau phosphorylated at threonine 181 (P-tau181), neurofilament light protein (NfL) and neurogranin (Ng) were measured. We tested the association between the CSF biomarkers and alcohol consumption types using correlation and linear regression, adjusting for possible confounders when necessary according to the performed sensitivity analysis.
Results: There were no correlations between weekly alcohol consumption and any of the CSF markers studied in the total sample of cognitively unimpaired participants (n = 246). After adjustments for multiplicity with FDR, there was an association between white wine and Ng in women with CDR = 0 (β:0.254, CI: ( 0.069: 0.439), p = 0.0076, FDR = 0.0455). Interaction analysis between female sex and red wine intake was a significant predictor of high Ng levels (β:0.410, CI: ( 0.099: 0.721), p = 0.0100, FDR = 0.0500). There were no correlations between consumption of specific types of alcohol (spirits, white wine, red wine, fortified wine, and beer) and any of the biomarkers studied in the total sample of cognitively unimpaired participants.
Conclusions: Our findings indicate that higher alcohol use in older cognitively unimpaired women correlates with a biomarker of synaptic dysfunction in AD, which is an important observation in a time when alcohol use is increasing among women.
期刊介绍：
Alzheimer's Research & Therapy is an international peer-reviewed journal that focuses on translational research into Alzheimer's disease and other neurodegenerative diseases. It publishes open-access basic research, clinical trials, drug discovery and development studies, and epidemiologic studies. The journal also includes reviews, viewpoints, commentaries, debates, and reports. All articles published in Alzheimer's Research & Therapy are included in several reputable databases such as CAS, Current contents, DOAJ, Embase, Journal Citation Reports/Science Edition, MEDLINE, PubMed, PubMed Central, Science Citation Index Expanded (Web of Science) and Scopus.
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