Yujiro Kawai, John A. Farag, Masataka Nishiga, Yu Liu, Koji Kawago, Tiffany K. Koyano, Robyn Fong, Mary Sheridan Bilbao, William Hiesinger, Hye Sook Shin, Eric M. Pfrender, Alex Dalal, Albert J. Pedroza, Jack H. Boyd, Y. Joseph Woo, Yasuhiro Shudo
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Comprehensive Analysis of Myocardial Reverse Remodeling Following HeartWare Ventricular Assist Device Implantation
As the prevalence of heart failure continues to rise, left ventricular assist devices (LVADs) have become an increasingly common treatment option for patients, demonstrating significant improvements in patient survival. LVAD therapy is also known to induce reverse remodeling, and its underlying mechanisms have garnered attention. This study examines the experience of end-stage heart failure patients who underwent HeartWare LVAD (HVAD, Medtronic Inc, Minneapolis, MN, USA) implantation. The patients were categorized into responder and non-responder groups to investigate the impact of LVAD therapy on hemodynamics, ventricular geometry, and transcriptomics in the heart before and after HVAD therapy. In the responder group, significant reductions in left ventricular size and improvements in left ventricular ejection fraction were observed. Furthermore, subtle enhancements in calcium cycling and unique gene expression changes were observed, which were notably different from the patterns observed in the non-responder group.
期刊介绍：
Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored.
Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include:
Immunology and immunosuppression;
Patient preparation;
Social, ethical, and psychological issues;
Complications, short- and long-term results;
Artificial organs;
Donation and preservation of organ and tissue;
Translational studies;
Advances in tissue typing;
Updates on transplant pathology;.
Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries.
Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.
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