{"title":"非传染性疾病合并症对银屑病患者的治疗结果有负面影响：中国上海的一项纵向研究","authors":"Quanruo Xu, Yuning Ding, Zhen Duan, Xiuqi Zhang, Ruiqi Cai, Xiangjin Gao, Rui Zhang, Ruiping Wang","doi":"10.1080/09546634.2025.2536113","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is frequently associated with non-communicable disease (NCD) comorbidities, prompting interest in how these concurrent conditions may influence psoriasis treatment outcomes.</p><p><strong>Objectives: </strong>To assess NCD prevalence and their influence on psoriasis treatment outcomes.</p><p><strong>Methods: </strong>From 2022 to 2024, we recruited psoriasis patients in Shanghai Skin Disease Hospital. Data on demographic features, NCD comorbidities and treatment outcomes at week 4 and week 8 were systematically collected through questionnaire, physical examination, and clinical severity assessment (psoriasis area and severity index [PASI], body surface area [BSA], physician's global assessment [PGA]).</p><p><strong>Results: </strong>Among 1116 patients, 48.4% had at least one NCD comorbidity. NCD-free patients exhibited higher PASI<sub>50</sub> response rates at both week 4 (46.5 <i>vs.</i> 39.1%) and week 8 (72.2 <i>vs.</i> 70.9%). Log binomial regression revealed that NCDs significantly reduced the likelihood of achieving PASI<sub>50</sub> at week 4 (relative risk [RR] = 0.84, 95% confidence interval [CI]: 0.73-0.96), with a similar but non-significant trend at week 8 (RR = 0.98, 95% CI: 0.92-1.06).</p><p><strong>Conclusion: </strong>NCDs negatively impact early treatment outcomes in psoriasis patients. So we propose that dermatologists should integrate systematic NCD management into psoriasis treatment regimen.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2536113"},"PeriodicalIF":3.9000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-communicable diseases comorbidities negatively impact the treatment outcomes among psoriasis patients: a longitudinal study in Shanghai, China.\",\"authors\":\"Quanruo Xu, Yuning Ding, Zhen Duan, Xiuqi Zhang, Ruiqi Cai, Xiangjin Gao, Rui Zhang, Ruiping Wang\",\"doi\":\"10.1080/09546634.2025.2536113\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Psoriasis is frequently associated with non-communicable disease (NCD) comorbidities, prompting interest in how these concurrent conditions may influence psoriasis treatment outcomes.</p><p><strong>Objectives: </strong>To assess NCD prevalence and their influence on psoriasis treatment outcomes.</p><p><strong>Methods: </strong>From 2022 to 2024, we recruited psoriasis patients in Shanghai Skin Disease Hospital. Data on demographic features, NCD comorbidities and treatment outcomes at week 4 and week 8 were systematically collected through questionnaire, physical examination, and clinical severity assessment (psoriasis area and severity index [PASI], body surface area [BSA], physician's global assessment [PGA]).</p><p><strong>Results: </strong>Among 1116 patients, 48.4% had at least one NCD comorbidity. NCD-free patients exhibited higher PASI<sub>50</sub> response rates at both week 4 (46.5 <i>vs.</i> 39.1%) and week 8 (72.2 <i>vs.</i> 70.9%). Log binomial regression revealed that NCDs significantly reduced the likelihood of achieving PASI<sub>50</sub> at week 4 (relative risk [RR] = 0.84, 95% confidence interval [CI]: 0.73-0.96), with a similar but non-significant trend at week 8 (RR = 0.98, 95% CI: 0.92-1.06).</p><p><strong>Conclusion: </strong>NCDs negatively impact early treatment outcomes in psoriasis patients. 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引用次数: 0
摘要
背景：牛皮癣经常与非传染性疾病（NCD）合并症相关，这些合并症如何影响牛皮癣治疗结果引起了人们的兴趣。目的：评估非传染性疾病患病率及其对银屑病治疗效果的影响。方法：于2022 - 2024年在上海皮肤病医院招募银屑病患者。通过问卷调查、体格检查和临床严重程度评估（牛皮癣面积和严重程度指数[PASI]、体表面积[BSA]、医生总体评估[PGA]）系统收集第4周和第8周的人口统计学特征、非传染性疾病合并症和治疗结果数据。结果：1116例患者中，48.4%的患者至少有一种非传染性疾病合并症。无非传染性疾病患者在第4周（46.5 vs 39.1%）和第8周（72.2 vs 70.9%）均表现出更高的PASI50缓解率。对数二项回归显示，非传染性疾病显著降低了患者在第4周达到PASI50的可能性（相对风险[RR] = 0.84, 95%可信区间[CI]: 0.73-0.96），在第8周也有类似但不显著的趋势（RR = 0.98, 95% CI: 0.92-1.06）。结论：非传染性疾病对银屑病患者的早期治疗结果有负面影响。因此，我们建议皮肤科医生将系统的非传染性疾病管理纳入银屑病治疗方案。
Non-communicable diseases comorbidities negatively impact the treatment outcomes among psoriasis patients: a longitudinal study in Shanghai, China.
Background: Psoriasis is frequently associated with non-communicable disease (NCD) comorbidities, prompting interest in how these concurrent conditions may influence psoriasis treatment outcomes.
Objectives: To assess NCD prevalence and their influence on psoriasis treatment outcomes.
Methods: From 2022 to 2024, we recruited psoriasis patients in Shanghai Skin Disease Hospital. Data on demographic features, NCD comorbidities and treatment outcomes at week 4 and week 8 were systematically collected through questionnaire, physical examination, and clinical severity assessment (psoriasis area and severity index [PASI], body surface area [BSA], physician's global assessment [PGA]).
Results: Among 1116 patients, 48.4% had at least one NCD comorbidity. NCD-free patients exhibited higher PASI50 response rates at both week 4 (46.5 vs. 39.1%) and week 8 (72.2 vs. 70.9%). Log binomial regression revealed that NCDs significantly reduced the likelihood of achieving PASI50 at week 4 (relative risk [RR] = 0.84, 95% confidence interval [CI]: 0.73-0.96), with a similar but non-significant trend at week 8 (RR = 0.98, 95% CI: 0.92-1.06).
Conclusion: NCDs negatively impact early treatment outcomes in psoriasis patients. So we propose that dermatologists should integrate systematic NCD management into psoriasis treatment regimen.
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