Philip Sandoval, Pallabi Mitra, Upendra A Argikar, Masanori Nakakariya, Diane Ramsden, Charles J Rotter, Kimio Tohyama, Paresh P Chothe
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引用次数: 0
摘要
我很高兴代表我的共同作者介绍我们的第五次年度审查，重点介绍在药物转运领域被认为有影响力的文章。随着新的转运体结构数据、体外/体内模型以及临床工具的应用，药物转运体领域正在迅速发展，以更好地了解它们在药物处置中的作用。每位合著者都选择了2024年的同行评议文章，并提供了简短的摘要和评论，就像我们之前的评议一样。（Chothe et al., 2021, 2022, 2023, 2024）。根据所选文章，本文分为以下几个部分：1)转运体结构和体外评价，2)新的体外/体内模型，3)内源性生物标志物和4)药物转运体和毒性。由于这些评论旨在提供文章的简要要点，因此鼓励读者查阅原文以了解更多细节。我还要感谢我的合著者多年来为这篇综述所做的工作和奉献。
Drug transporters in drug disposition - highlights from the year 2024.
On behalf of my coauthors, I am pleased to present our fifth annual review highlighting articles in the field of drug transporters that have been deemed as influential. The field of drug-transporters is rapidly evolving with new transporter structure data, in vitro/in vivo models in addition to clinical tools being applied to better understand their role in drug disposition. Each coauthor has selected peer-reviewed articles from the year 2024 and provided a brief summary with a commentary, as done in our previous reviews. (Chothe et al. 2021, 2022,2023, 2024). The review is divided into the following sections based on the selected articles: 1) transporter structure and in vitro evaluation, 2) novel in vitro/in vivo models, 3) endogenous biomarkers and 4) drug transporters and toxicity. As these commentaries are meant to provide brief highlights of the articles, readers are encouraged to consult the original articles for further details. I would also like to thank my coauthors for their work and dedication to this review over the years.
期刊介绍：
Drug Metabolism Reviews consistently provides critically needed reviews of an impressive array of drug metabolism research-covering established, new, and potential drugs; environmentally toxic chemicals; absorption; metabolism and excretion; and enzymology of all living species. Additionally, the journal offers new hypotheses of interest to diverse groups of medical professionals including pharmacologists, toxicologists, chemists, microbiologists, pharmacokineticists, immunologists, mass spectroscopists, as well as enzymologists working in xenobiotic biotransformation.
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