Naonori Hu, Taiki Nakamura, Ryusuke Kataura, Keita Suga, Tetsuya Mukawa, Kazuhiko Akita, Ryo Kakino, Akinori Sasaki, Mai Nojiri, Nishiki Matsubayashi, Takushi Takata, Hiroki Tanaka, Keiji Nihei, Koji Ono
{"title":"用于临床硼中子俘获治疗的加速器中子系统的常规质量保证的实时中子监测系统的实现","authors":"Naonori Hu, Taiki Nakamura, Ryusuke Kataura, Keita Suga, Tetsuya Mukawa, Kazuhiko Akita, Ryo Kakino, Akinori Sasaki, Mai Nojiri, Nishiki Matsubayashi, Takushi Takata, Hiroki Tanaka, Keiji Nihei, Koji Ono","doi":"10.1002/acm2.70190","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Currently, the metal foil activation method is routinely used to measure the neutron output of an accelerator-based neutron source designed for clinical Boron neutron capture therapy (BNCT). Although this method is well established and has been primarily utilized since the nuclear reactor BNCT era, the process is labour-intensive and not well-suited for a busy hospital environment performing routine patient treatment. A replacement neutron detector system that is simple to use and can measure the neutron output in real-time is necessary.</p>\n </section>\n \n <section>\n \n <h3> Purpose</h3>\n \n <p>Investigation and implementation of an Eu doped LiCaAlF<sub>6</sub> scintillator detector for use in routine quality assurance tests of an accelerator-based neutron source designed for clinical BNCT.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The response of the scintillator detector was evaluated using the NeuCure BNCT system installed at the Kansai BNCT Medical Center. The measurement repeatability, neutron fluence linearity, and neutron flux dependency of the detector system were evaluated. The beam central axis and off-axis thermal neutron distribution inside a water phantom were measured and compared with the Monte Carlo treatment planning system (TPS).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The scintillator detector system showed high measurement repeatability with a coefficient of variation of less than 0.4%. The detector system showed linear response up to a proton charge of 3.6 C, and the response was stable between a proton current of 0.1 and 1 mA. Both the central axis and off-axis thermal neutron flux inside a water phantom matched closely with both the metal foil activation method and the Monte Carlo simulation results. The time it took to perform a routine quality assurance test was drastically reduced from 1.5 h down to a few minutes.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Implementation of this detector system in the clinic would significantly reduce the time required for routine QA, acceptance, and commissioning, and be a stepping stone to assist expansion of accelerator-based BNCT systems worldwide.</p>\n </section>\n </div>","PeriodicalId":14989,"journal":{"name":"Journal of Applied Clinical Medical Physics","volume":"26 8","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm2.70190","citationCount":"0","resultStr":"{\"title\":\"Implementation of a real-time neutron monitor system for use in routine quality assurance of an accelerator-based neutron system for clinical boron neutron capture therapy\",\"authors\":\"Naonori Hu, Taiki Nakamura, Ryusuke Kataura, Keita Suga, Tetsuya Mukawa, Kazuhiko Akita, Ryo Kakino, Akinori Sasaki, Mai Nojiri, Nishiki Matsubayashi, Takushi Takata, Hiroki Tanaka, Keiji Nihei, Koji Ono\",\"doi\":\"10.1002/acm2.70190\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Currently, the metal foil activation method is routinely used to measure the neutron output of an accelerator-based neutron source designed for clinical Boron neutron capture therapy (BNCT). Although this method is well established and has been primarily utilized since the nuclear reactor BNCT era, the process is labour-intensive and not well-suited for a busy hospital environment performing routine patient treatment. A replacement neutron detector system that is simple to use and can measure the neutron output in real-time is necessary.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>Investigation and implementation of an Eu doped LiCaAlF<sub>6</sub> scintillator detector for use in routine quality assurance tests of an accelerator-based neutron source designed for clinical BNCT.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The response of the scintillator detector was evaluated using the NeuCure BNCT system installed at the Kansai BNCT Medical Center. The measurement repeatability, neutron fluence linearity, and neutron flux dependency of the detector system were evaluated. The beam central axis and off-axis thermal neutron distribution inside a water phantom were measured and compared with the Monte Carlo treatment planning system (TPS).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The scintillator detector system showed high measurement repeatability with a coefficient of variation of less than 0.4%. The detector system showed linear response up to a proton charge of 3.6 C, and the response was stable between a proton current of 0.1 and 1 mA. Both the central axis and off-axis thermal neutron flux inside a water phantom matched closely with both the metal foil activation method and the Monte Carlo simulation results. 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Implementation of a real-time neutron monitor system for use in routine quality assurance of an accelerator-based neutron system for clinical boron neutron capture therapy
Background
Currently, the metal foil activation method is routinely used to measure the neutron output of an accelerator-based neutron source designed for clinical Boron neutron capture therapy (BNCT). Although this method is well established and has been primarily utilized since the nuclear reactor BNCT era, the process is labour-intensive and not well-suited for a busy hospital environment performing routine patient treatment. A replacement neutron detector system that is simple to use and can measure the neutron output in real-time is necessary.
Purpose
Investigation and implementation of an Eu doped LiCaAlF6 scintillator detector for use in routine quality assurance tests of an accelerator-based neutron source designed for clinical BNCT.
Methods
The response of the scintillator detector was evaluated using the NeuCure BNCT system installed at the Kansai BNCT Medical Center. The measurement repeatability, neutron fluence linearity, and neutron flux dependency of the detector system were evaluated. The beam central axis and off-axis thermal neutron distribution inside a water phantom were measured and compared with the Monte Carlo treatment planning system (TPS).
Results
The scintillator detector system showed high measurement repeatability with a coefficient of variation of less than 0.4%. The detector system showed linear response up to a proton charge of 3.6 C, and the response was stable between a proton current of 0.1 and 1 mA. Both the central axis and off-axis thermal neutron flux inside a water phantom matched closely with both the metal foil activation method and the Monte Carlo simulation results. The time it took to perform a routine quality assurance test was drastically reduced from 1.5 h down to a few minutes.
Conclusion
Implementation of this detector system in the clinic would significantly reduce the time required for routine QA, acceptance, and commissioning, and be a stepping stone to assist expansion of accelerator-based BNCT systems worldwide.
期刊介绍：
Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission.
JACMP will publish:
-Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500.
-Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed.
-Technical Notes: These should be no longer than 3000 words, including key references.
-Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents.
-Book Reviews: The editorial office solicits Book Reviews.
-Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics.
-Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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