肥胖持续时间通过脂肪组织反应与减肥手术结果相关。

IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Journal of Endocrinology Pub Date : 2025-08-06 Print Date: 2025-08-01 DOI:10.1530/JOE-25-0013
Julia Sánchez-Ceinos, Bethan C Townsend, Carmen Tercero-Alcázar, Jaime López-Alcalá, Ignacio Ortea, Salvador Morales-Conde, José L Pereira-Cunill, Pedro P García-Luna, David A Cano, María M Malagón, Rocío Guzmán-Ruiz
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引用次数: 0

摘要

减肥手术(BS)是肥胖及其相关合并症最有效的治疗方法,可导致显著的脂肪组织(AT)损失和功能恢复。然而,AT中驱动这些健康益处的分子机制仍然知之甚少,目前需要适当减肥的预测因素。本研究旨在确定与bs诱导的体重减轻和代谢改善相关的皮下AT (SAT)的蛋白质组学特征,并确定个体反应的潜在预测因素。对肥胖患者在BS前后的配对腹部SAT样本进行了全理论质谱序列窗口采集(SWATH-MS)蛋白质组学研究。对蛋白质组学数据与人体测量学和临床参数的变化进行了生物信息学和相关性分析。此外,体外评估了BS参与者血清对皮下脂肪细胞的影响。SAT对BS的反应表现为线粒体代谢上调和炎症下调,这与不同的人体测量和循环指标相关。值得注意的是,肥胖持续时间与bs诱导的体重减轻有关。与长期肥胖(LSO)相比,短期肥胖(SSO)个体在bs后表现出更大的蛋白质组重塑、体重减轻和临床改善。此外,脂肪细胞中涉及miR-223-3p、葡萄糖代谢和细胞骨架重组的调控轴可能与BS在LSO中的积极作用有关。总体而言,我们的研究结果表明,肥胖持续时间与bs通过SAT蛋白质组重塑诱导的体重减轻有关。解决这种关系可以帮助制定新的策略来加强肥胖人群的体重管理和代谢健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Obesity duration is linked to bariatric surgery outcomes via adipose tissue response.

Bariatric surgery (BS) is the most effective treatment for obesity and its related comorbidities, resulting in significant adipose tissue (AT) loss and functional recovery. However, the molecular mechanisms in the AT that drive these health benefits remain poorly understood, and predictive factors for adequate weight loss are currently needed. This study aimed to identify the proteomic signature of subcutaneous AT (SAT) linked to BS-induced weight loss and metabolic improvement, and to determine potential predictors of individual response. Sequential window acquisition of all theoretical mass spectra (SWATH-MS) proteomics was performed on paired abdominal SAT samples from individuals with obesity before and after BS. Bioinformatic and correlation analyses were conducted between proteomic data and changes in anthropometric and clinical parameters. In addition, the effect of sera from BS participants on subcutaneous adipocytes was assessed in vitro. The SAT response to BS was characterised by an up-regulation of mitochondrial metabolism and a down-regulation of inflammation, which correlated with different anthropometric and circulating markers. Notably, obesity duration was associated with BS-induced weight loss. Individuals with short-standing obesity (SSO) exhibited greater proteomic remodelling, weight reduction, and clinical improvement post-BS than those with long-standing obesity (LSO). Furthermore, a regulatory axis involving miR-223-3p, glucose metabolism, and cytoskeleton reorganisation in adipocytes might be connected to the positive effects of BS in LSO. Overall, our results indicate that obesity duration is related to BS-induced weight loss through SAT proteomic remodelling. Addressing this relationship could help develop new strategies to enhance weight management and metabolic health in people living with obesity.

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来源期刊
Journal of Endocrinology
Journal of Endocrinology 医学-内分泌学与代谢
CiteScore
7.90
自引率
2.50%
发文量
113
审稿时长
4-8 weeks
期刊介绍: Journal of Endocrinology is a leading global journal that publishes original research articles, reviews and science guidelines. Its focus is on endocrine physiology and metabolism, including hormone secretion; hormone action; biological effects. The journal publishes basic and translational studies at the organ, tissue and whole organism level.
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