急性髓系白血病分子分型与预后预测细胞粘附相关特征的鉴定。

IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Caifang Zhao, Xiang Weng, Wei He
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引用次数: 0

摘要

背景:急性髓系白血病(AML)是一种异质性血液系统恶性肿瘤,其复杂的分子特征显著影响预后和治疗反应。尽管取得了相当大的进展,但有效的风险分层和个性化治疗的预测性生物标志物仍然不足。细胞粘附相关基因在AML进展中的作用尚未得到充分探讨。方法:根据细胞粘附相关基因的表达模式,将AML患者分为不同的分子亚型。随后进行富集分析以确定相关的生物学途径。鉴定差异表达基因,并通过Lasso回归和多变量Cox回归筛选出8个具有预后意义的基因。然后使用这些基因构建预后模型,并使用外部数据集验证该模型。通过免疫细胞浸润和药物敏感性分析,评价模型的实用性。结果:确定了两种AML分子亚型,每种亚型都与不同的生物学途径相关。建立了一个包含8个基因的预后模型,对总体生存具有很强的预测能力,并与免疫细胞浸润模式有显著相关性。药物敏感性分析确定了潜在的治疗靶点和候选药物,为AML的治疗提供了新的方向。结论:这项研究揭示了由细胞粘附相关基因驱动的新型AML亚型,为遗传异质性、免疫景观和治疗脆弱性提供了见解。发展的预后模型和确定的候选治疗方案为AML的预后预测和个性化治疗策略提供了有价值的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of cell adhesion related signature for molecular subtyping and prognostic prediction in acute myeloid leukemia.

Background: Acute Myeloid Leukemia (AML) is a heterogeneous hematologic malignancy, characterized by complex molecular features that significantly impact prognosis and therapeutic responses. Despite considerable progress, effective risk stratification and predictive biomarkers for personalized therapies remain inadequate. The involvement of cell adhesion-related genes in the progression of AML has yet to be fully explored.

Methods: AML patients were grouped into distinct molecular subtypes based on the expression patterns of cell adhesion-related genes. Enrichment analyses were subsequently performed to identify associated biological pathways. Differentially expressed genes were identified, and through Lasso regression and multivariate Cox regression, eight prognostically significant genes were selected. These genes were then used to construct a prognostic model, which was validated using external datasets. Furthermore, analyses of immune cell infiltration and drug sensitivity were conducted to evaluate the practical applicability of the model.

Results: Two AML molecular subtypes were identified, each linked to distinct biological pathways. A prognostic model comprising 8 genes was developed, showing strong predictive power for overall survival and significant correlations with immune cell infiltration patterns. Drug sensitivity analyses identified potential therapeutic targets and candidate drugs, offering new directions for AML treatment.

Conclusion: This study reveals novel AML subtypes driven by cell adhesion-related genes, providing insights into genetic heterogeneity, immune landscape, and therapeutic vulnerabilities. The developed prognostic model and identified therapeutic candidates offer valuable tools for prognosis prediction and personalized treatment strategies in AML.

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来源期刊
Discover. Oncology
Discover. Oncology Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.40
自引率
9.10%
发文量
122
审稿时长
5 weeks
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