铜催化烯烃的对映选择性酰基氰化反应。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-24 DOI:10.1021/acs.orglett.5c02373

Anurag Biswas, Subramanian Srikriya and Pazhamalai Anbarasan*,

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引用次数: 0

摘要

研究了一种铜催化的烯烃对映选择性酰基氰化反应的不对称邻二碳功能化反应。该方案避免了使用昂贵的光催化剂，并展示了广泛的底物范围，以提供各种β-氰基酮具有非常高的对映纯度（高达bbb99:1 er）和产率（高达86%）。初步的机理研究也进行了，提供了有价值的见解的反应路径。此外，β-氰酮的几个官能团转化已经进行，以显示该策略的广泛合成效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Copper-Catalyzed Enantioselective Acylcyanation of Alkenes

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Copper-Catalyzed Enantioselective Acylcyanation of Alkenes

An efficient copper-catalyzed asymmetric vicinal dicarbofunctionalization has been developed for the enantioselective acylcyanation of olefins. The protocol avoids the use of expensive photocatalysts, and showcases a broad substrate scope to afford various β-cyano ketones with very high enantiopurity (up to >99:1 er) and yields (up to 86%). A preliminary mechanistic study has also been conducted, which provided valuable insights into the reaction paths. Furthermore, several functional group transformations in β-cyanoketone have been performed to show the wide synthetic utility of the strategy.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.