Irene Gonzalez-Alaña, Patricia Martin-Playa, Leire Aparicio-Elizalde, Unay Yilmaz-Bescos, Francisco Casquero-Ocio, Itziar Valverde-Pascual, Silvia Perez-Fernandez, Jaime Carames-Estefania, Iñigo San Miguel-Arregui
{"title":"术后近距离放疗治疗瘢痕疙瘩:一项单中心研究。","authors":"Irene Gonzalez-Alaña, Patricia Martin-Playa, Leire Aparicio-Elizalde, Unay Yilmaz-Bescos, Francisco Casquero-Ocio, Itziar Valverde-Pascual, Silvia Perez-Fernandez, Jaime Carames-Estefania, Iñigo San Miguel-Arregui","doi":"10.5114/jcb.2025.151825","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>A keloid is a benign fibro-dermal tumor that produces an excess deposit of extra-cellular matrix. It usually occurs after a skin lesion, and it spreads beyond the wound. It is characterized by high recurrence rate after excision and lack of tendency of spontaneous involution. Multiple treatments have been described, with recurrence rates of up to 100%. One of the treatments considered most effective is combined therapy, i.e., surgery and subsequent radiotherapy using interstitial irradiation with iridium-192 (brachytherapy), with a clear reduction in recurrence rate.</p><p><strong>Material and methods: </strong>In our center, the technique was introduced in 2012, and the current retrospective observational study was conducted among 27 patients treated till December 2020.</p><p><strong>Results: </strong>The recurrence rate in the study was 25%, of which 83% recurred partially.</p><p><strong>Conclusions: </strong>The most frequent complications observed were dehiscence and infection of the surgical wound, therefore this therapeutic approach can be considered both safe and effective.</p>","PeriodicalId":51305,"journal":{"name":"Journal of Contemporary Brachytherapy","volume":"17 3","pages":"153-159"},"PeriodicalIF":1.1000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277957/pdf/","citationCount":"0","resultStr":"{\"title\":\"Post-surgical brachytherapy in the treatment of keloids: A single-center study.\",\"authors\":\"Irene Gonzalez-Alaña, Patricia Martin-Playa, Leire Aparicio-Elizalde, Unay Yilmaz-Bescos, Francisco Casquero-Ocio, Itziar Valverde-Pascual, Silvia Perez-Fernandez, Jaime Carames-Estefania, Iñigo San Miguel-Arregui\",\"doi\":\"10.5114/jcb.2025.151825\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>A keloid is a benign fibro-dermal tumor that produces an excess deposit of extra-cellular matrix. It usually occurs after a skin lesion, and it spreads beyond the wound. It is characterized by high recurrence rate after excision and lack of tendency of spontaneous involution. Multiple treatments have been described, with recurrence rates of up to 100%. One of the treatments considered most effective is combined therapy, i.e., surgery and subsequent radiotherapy using interstitial irradiation with iridium-192 (brachytherapy), with a clear reduction in recurrence rate.</p><p><strong>Material and methods: </strong>In our center, the technique was introduced in 2012, and the current retrospective observational study was conducted among 27 patients treated till December 2020.</p><p><strong>Results: </strong>The recurrence rate in the study was 25%, of which 83% recurred partially.</p><p><strong>Conclusions: </strong>The most frequent complications observed were dehiscence and infection of the surgical wound, therefore this therapeutic approach can be considered both safe and effective.</p>\",\"PeriodicalId\":51305,\"journal\":{\"name\":\"Journal of Contemporary Brachytherapy\",\"volume\":\"17 3\",\"pages\":\"153-159\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277957/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Contemporary Brachytherapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5114/jcb.2025.151825\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Contemporary Brachytherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/jcb.2025.151825","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/4 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Post-surgical brachytherapy in the treatment of keloids: A single-center study.
Purpose: A keloid is a benign fibro-dermal tumor that produces an excess deposit of extra-cellular matrix. It usually occurs after a skin lesion, and it spreads beyond the wound. It is characterized by high recurrence rate after excision and lack of tendency of spontaneous involution. Multiple treatments have been described, with recurrence rates of up to 100%. One of the treatments considered most effective is combined therapy, i.e., surgery and subsequent radiotherapy using interstitial irradiation with iridium-192 (brachytherapy), with a clear reduction in recurrence rate.
Material and methods: In our center, the technique was introduced in 2012, and the current retrospective observational study was conducted among 27 patients treated till December 2020.
Results: The recurrence rate in the study was 25%, of which 83% recurred partially.
Conclusions: The most frequent complications observed were dehiscence and infection of the surgical wound, therefore this therapeutic approach can be considered both safe and effective.
期刊介绍:
The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.