早期食管癌及癌前病变的内镜下粘膜夹层与内镜下粘膜切除术的临床优势比较

IF 1.1 4区 医学 Q3 SURGERY
Xiaoting Hou, Tingting Ding, Gai Zhou, Guanqi Liu, Rui Yin, Jing Ying, Jianxin Ge, Yongjian Lv
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引用次数: 0

摘要

目的:比较内镜下粘膜切除(EMR)与内镜下粘膜剥离(ESD)治疗早期食管癌的疗效。对象与方法:选取我院2021年11月至2023年12月收治的早期食管癌及癌前病变患者86例,随机分为治疗组(ESD) 43例和对照组(EMR) 43例。比较两种方法的疗效和安全性。结果:ESD组手术时间(117.65±19.98)明显长于EMR组(P < 0.05)。ESD组患者住院时间(7.51±1.30 d)短于EMR组(9.16±2.01 d) (P < 0.05)。ESD组患者的整体切除率、完全切除率和治愈率(分别为100.0%、95.35%和93.02%)与EMR组患者的整体切除率、完全切除率和治愈率(分别为100.0%、93.02%和90.70%)比较(P < 0.05)。ESD组术后并发症发生率为4.65%,低于EMR组的13.95% (P < 0.05)。两组患者原发病灶均未发生复发或转移。两组患者术后生活质量均优于术前。ESD组患者的生存质量明显优于EMR组(P < 0.05)。结论:与EMR相比,ESD治疗早期食管癌及癌前病变的临床效果更好,术后并发症更少,安全性更高。然而,病变的直径应考虑到最佳的手术计划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The clinical advantages of endoscopic submucosal dissection compared with endoscopic mucosal resection for early oesophageal cancer and pre-cancer lesions.

Objective: The objective of the study was to compare the effects of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in the treatment of early oesophageal cancer.

Subjects and methods: Eighty-six patients with early oesophageal cancer and precancerous lesions admitted to our hospital from November 2021 to December 2023 were randomly divided into a treatment group (ESD: 43 cases) and control group (EMR: 43 cases). The efficacy and safety of the two methods were compared.

Results: The operation time of ESD was 117.65 ± 19.98, which was longer than that of EMR group (P < 0.05). The hospitalization time of patients in the ESD group was shorter than that in the EMR group (7.51 ± 1.30 vs. 9.16 ± 2.01 days, P < 0.05). Comparable en bloc resection rate, complete resection rate, and curative resection rate of patients in the ESD group (100.0%, 95.35%, and 93.02%) and EMR group (100.0%, 93.02%, and 90.70%) were observed (P > 0.05). The incidence of postoperative complications in the ESD group was 4.65%, which was lower than 13.95% in the EMR group (P > 0.05). No recurrence or metastasis of the primary lesions occurred in both groups. Both groups were displaying better postoperative life quality comparing to that of pre-operation. The quality of life in the ESD group was significantly better than that of the EMR group (P < 0.05).

Conclusion: Compared with EMR, ESD showed better clinical effects, fewer postoperative complications and higher safety in treating early oesophageal cancer and precancerous lesions. However, the diameter of the lesion should be considered for an optimal surgical plan.

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来源期刊
CiteScore
1.70
自引率
0.00%
发文量
151
审稿时长
36 weeks
期刊介绍: Journal of Minimal Access Surgery (JMAS), the official publication of Indian Association of Gastrointestinal Endo Surgeons, launched in early 2005. The JMAS, a quarterly publication, is the first English-language journal from India, as also from this part of the world, dedicated to Minimal Access Surgery. The JMAS boasts an outstanding editorial board comprising of Indian and international experts in the field.
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