{"title":"根据日本脑肿瘤幻像试验对数字氧化铋锗PET/CT系统进行18f氟化影成像评价。","authors":"Shohei Fukai, Hiromitsu Daisaki, Honoka Yoshida, Naoki Shimada, Kazuki Motegi, Atsushi Osawa, Takashi Terauchi","doi":"10.1007/s13246-025-01608-z","DOIUrl":null,"url":null,"abstract":"<p><p>The Omni Legend (GE Healthcare), equipped with a digital bismuth germanium oxide PET/CT system, has been recently developed. However, the performance of the Omni Legend without a time-of-flight (TOF) system for <sup>18</sup>F-fluciclovine imaging is still unclear. Therefore, this study evaluated the image quality of the Omni Legend according to the Japanese brain tumor phantom test (JBT) criteria, and assessed its potential use for <sup>18</sup>F-fluciclovine imaging. This study followed the JBT procedures. A brain tumor phantom, which includes six hot spheres of different diameters, was filled with an <sup>18</sup>F-fluorodeoxyglucose solution with a radioactivity concentration ratio of 3 (spheres):1 (background). PET scanning was performed using the Omni Legend with a 30-min list mode acquisition. The PET data were reconstructed using an ordered subset expectation maximization (OSEM), an OSEM with point spread function (OSEM + PSF), and a Bayesian penalized likelihood (BPL) under standard clinical parameters. The image quality was evaluated using the JBT criteria, including contrast for a 7.5-mm sphere, recovery coefficient (RC) for a 10.0-mm sphere, standardized uptake value of total background (SUV<sub>TOT</sub>), and detectability for a 7.5-mm sphere. The contrast, RC, and SUV<sub>TOT</sub> were 25.1%, 0.70, and 1.00, respectively in OSEM; 25.8%, 0.80, and 0.99 in OSEM + PSF; and 33.8%, 0.93, and 0.99 in BPL. The 7.5-mm sphere was detected by all three methods. All of the JBT criteria were satisfied, regardless of the PET image reconstruction methods. This study demonstrated that the Omni Legend without TOF satisfies all JBT criteria and has the potential to provide high-quality images in <sup>18</sup>F-fluciclovine imaging.</p>","PeriodicalId":48490,"journal":{"name":"Physical and Engineering Sciences in Medicine","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of a digital bismuth germanium oxide PET/CT system according to the Japanese brain tumor phantom test for <sup>18</sup>F-fluciclovine imaging.\",\"authors\":\"Shohei Fukai, Hiromitsu Daisaki, Honoka Yoshida, Naoki Shimada, Kazuki Motegi, Atsushi Osawa, Takashi Terauchi\",\"doi\":\"10.1007/s13246-025-01608-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Omni Legend (GE Healthcare), equipped with a digital bismuth germanium oxide PET/CT system, has been recently developed. However, the performance of the Omni Legend without a time-of-flight (TOF) system for <sup>18</sup>F-fluciclovine imaging is still unclear. Therefore, this study evaluated the image quality of the Omni Legend according to the Japanese brain tumor phantom test (JBT) criteria, and assessed its potential use for <sup>18</sup>F-fluciclovine imaging. This study followed the JBT procedures. A brain tumor phantom, which includes six hot spheres of different diameters, was filled with an <sup>18</sup>F-fluorodeoxyglucose solution with a radioactivity concentration ratio of 3 (spheres):1 (background). PET scanning was performed using the Omni Legend with a 30-min list mode acquisition. The PET data were reconstructed using an ordered subset expectation maximization (OSEM), an OSEM with point spread function (OSEM + PSF), and a Bayesian penalized likelihood (BPL) under standard clinical parameters. The image quality was evaluated using the JBT criteria, including contrast for a 7.5-mm sphere, recovery coefficient (RC) for a 10.0-mm sphere, standardized uptake value of total background (SUV<sub>TOT</sub>), and detectability for a 7.5-mm sphere. The contrast, RC, and SUV<sub>TOT</sub> were 25.1%, 0.70, and 1.00, respectively in OSEM; 25.8%, 0.80, and 0.99 in OSEM + PSF; and 33.8%, 0.93, and 0.99 in BPL. The 7.5-mm sphere was detected by all three methods. All of the JBT criteria were satisfied, regardless of the PET image reconstruction methods. This study demonstrated that the Omni Legend without TOF satisfies all JBT criteria and has the potential to provide high-quality images in <sup>18</sup>F-fluciclovine imaging.</p>\",\"PeriodicalId\":48490,\"journal\":{\"name\":\"Physical and Engineering Sciences in Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physical and Engineering Sciences in Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13246-025-01608-z\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physical and Engineering Sciences in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13246-025-01608-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Evaluation of a digital bismuth germanium oxide PET/CT system according to the Japanese brain tumor phantom test for 18F-fluciclovine imaging.
The Omni Legend (GE Healthcare), equipped with a digital bismuth germanium oxide PET/CT system, has been recently developed. However, the performance of the Omni Legend without a time-of-flight (TOF) system for 18F-fluciclovine imaging is still unclear. Therefore, this study evaluated the image quality of the Omni Legend according to the Japanese brain tumor phantom test (JBT) criteria, and assessed its potential use for 18F-fluciclovine imaging. This study followed the JBT procedures. A brain tumor phantom, which includes six hot spheres of different diameters, was filled with an 18F-fluorodeoxyglucose solution with a radioactivity concentration ratio of 3 (spheres):1 (background). PET scanning was performed using the Omni Legend with a 30-min list mode acquisition. The PET data were reconstructed using an ordered subset expectation maximization (OSEM), an OSEM with point spread function (OSEM + PSF), and a Bayesian penalized likelihood (BPL) under standard clinical parameters. The image quality was evaluated using the JBT criteria, including contrast for a 7.5-mm sphere, recovery coefficient (RC) for a 10.0-mm sphere, standardized uptake value of total background (SUVTOT), and detectability for a 7.5-mm sphere. The contrast, RC, and SUVTOT were 25.1%, 0.70, and 1.00, respectively in OSEM; 25.8%, 0.80, and 0.99 in OSEM + PSF; and 33.8%, 0.93, and 0.99 in BPL. The 7.5-mm sphere was detected by all three methods. All of the JBT criteria were satisfied, regardless of the PET image reconstruction methods. This study demonstrated that the Omni Legend without TOF satisfies all JBT criteria and has the potential to provide high-quality images in 18F-fluciclovine imaging.