{"title":"过敏反应中的人肥大细胞：从研究到诊断。","authors":"Jessy Elst, Didier G Ebo, Vito Sabato","doi":"10.1097/ACI.0000000000001092","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Mast cell degranulation in anaphylaxis can result from both IgE-dependent and IgE-independent mechanisms. The two conditions differ in terms of phenotype, diagnosis and specific therapeutic targets.</p><p><strong>Recent findings: </strong>Genetic factors and IgE-sialylation might enhance IgE-dependent degranulation. MRGPRX2-dependent signal might have a synergistic effect on IgE-dependent degranulation. The data on IgG-dependent anaphylaxis highlight the significance of histamine release from mast cells. Recent advances in the field have led to the development of novel targeting treatments for both IgE-dependent and IgE-independent mast cell degranulation.</p><p><strong>Summary: </strong>In-vitro analysis of human mast cells offers the possibility of studying the mechanisms underlying mast cell degranulation in anaphylaxis. The implementation of this analysis in clinical practice can advance diagnosis. Moreover, mechanistic and preclinical studies support the development of targeted treatments for IgE-dependent and IgE-independent anaphylaxis.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"315-321"},"PeriodicalIF":2.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Human mast cells in anaphylaxis: from research to diagnosis.\",\"authors\":\"Jessy Elst, Didier G Ebo, Vito Sabato\",\"doi\":\"10.1097/ACI.0000000000001092\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>Mast cell degranulation in anaphylaxis can result from both IgE-dependent and IgE-independent mechanisms. The two conditions differ in terms of phenotype, diagnosis and specific therapeutic targets.</p><p><strong>Recent findings: </strong>Genetic factors and IgE-sialylation might enhance IgE-dependent degranulation. MRGPRX2-dependent signal might have a synergistic effect on IgE-dependent degranulation. The data on IgG-dependent anaphylaxis highlight the significance of histamine release from mast cells. Recent advances in the field have led to the development of novel targeting treatments for both IgE-dependent and IgE-independent mast cell degranulation.</p><p><strong>Summary: </strong>In-vitro analysis of human mast cells offers the possibility of studying the mechanisms underlying mast cell degranulation in anaphylaxis. The implementation of this analysis in clinical practice can advance diagnosis. Moreover, mechanistic and preclinical studies support the development of targeted treatments for IgE-dependent and IgE-independent anaphylaxis.</p>\",\"PeriodicalId\":10956,\"journal\":{\"name\":\"Current Opinion in Allergy and Clinical Immunology\",\"volume\":\" \",\"pages\":\"315-321\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Allergy and Clinical Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/ACI.0000000000001092\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Allergy and Clinical Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/ACI.0000000000001092","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/23 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}
Human mast cells in anaphylaxis: from research to diagnosis.
Purpose of review: Mast cell degranulation in anaphylaxis can result from both IgE-dependent and IgE-independent mechanisms. The two conditions differ in terms of phenotype, diagnosis and specific therapeutic targets.
Recent findings: Genetic factors and IgE-sialylation might enhance IgE-dependent degranulation. MRGPRX2-dependent signal might have a synergistic effect on IgE-dependent degranulation. The data on IgG-dependent anaphylaxis highlight the significance of histamine release from mast cells. Recent advances in the field have led to the development of novel targeting treatments for both IgE-dependent and IgE-independent mast cell degranulation.
Summary: In-vitro analysis of human mast cells offers the possibility of studying the mechanisms underlying mast cell degranulation in anaphylaxis. The implementation of this analysis in clinical practice can advance diagnosis. Moreover, mechanistic and preclinical studies support the development of targeted treatments for IgE-dependent and IgE-independent anaphylaxis.
期刊介绍：
This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.
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