尿路感染的现代解决方案:纳米技术和草药治疗的作用。

IF 2.5 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Ashutosh Kumar, Amit Kumar, Md Moidul Islam, Ranadeep Borgohain, Sarjana Raikwar
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引用次数: 0

摘要

导读:尿路感染(UTIs)从轻微到严重不等,通常由尿路致病性大肠杆菌(E. coli)引起。对抗生素耐药性的日益关注需要替代治疗策略。纳米技术,特别是纳米载体,通过增强药物传递、抗菌活性和靶向治疗,提供了一个有前途的解决方案。这篇综述的重点是结合草药和纳米技术对尿路感染进行更有效和个性化管理的新作用,旨在克服传统抗生素治疗的局限性。方法:本综述广泛检索了科学数据库和相关文献,包括PubMed、Science Direct和谷歌Scholar上迄今发表的研究。尿路感染(UTI)、抗生素耐药性、纳米技术、药物传递、靶向药物传递和草药都是使用的搜索短语。结果:研究表明,印度楝树和姜黄等草药提取物与纳米技术结合可显著增强对尿路感染病原菌的抗菌活性。这些纳米制剂显示出增强的细菌抑制,减少炎症,提高治疗精度和最小的副作用。讨论:草药和纳米载体的协同使用为管理uti提供了一种新的方法。纳米技术不仅增强了药物的传递,而且通过荧光标记和生物分子标记提高了诊断的准确性。这一战略有效地解决了日益增长的抗生素耐药性问题,并支持个性化治疗的发展。天然生物活性物质与先进的给药系统相结合,为治疗尿路感染提供了一种比传统抗生素更安全、更有效的选择。结论:纳米技术与草药疗法的结合使尿路感染的精准医疗管理发生了革命性的变化。这种方法提高了治疗效果、诊断准确性和患者预后,提供了一种个性化的解决方案,以对抗抗生素耐药性和尿路异常,具有更好的靶向性和最小的副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modern Solutions to UTIs: The Role of Nanotechnology and Herbal Treatments.

Introduction: Urinary tract infections (UTIs) range from mild to severe cases, commonly caused by uropathogenic Escherichia coli (E. coli). The growing concern about antibiotic resistance demands alternative treatment strategies. Nanotechnology, particularly nanocarriers, presents a promising solution by enhancing drug delivery, antibacterial activity, and targeted therapy. This review focuses on the emerging role of combining herbal remedies with nanotechnology for more effective and personalized management of UTIs, aiming to overcome the limitations of conventional antibiotic therapies.

Methods: The review involved an extensive search of scientific databases and relevant literature, including studies published to date from PubMed, Science Direct, and Google Scholar. Urinary tract infections (UTI), antibiotic resistance, nanotechnology, drug delivery, targeted drug delivery, and herbal drugs were among the search phrases used.

Result: According to studies, combining herbal extracts such as neem and turmeric with nanotechnology significantly enhances antimicrobial activity against UTI pathogens. These nanoformulations show enhanced bacterial inhibition, reduced inflammation, and increased therapeutic precision with minimal side effects.

Discussion: The synergistic use of herbal remedies and nanocarriers offers a novel approach to managing UTIs. Nanotechnology not only enhances drug delivery but also improves diagnostic accuracy through fluorescence markers and biomolecule tagging. This strategy effectively addresses growing antibiotic resistance and supports the development of personalized treatments. The combination of natural bioactives and advanced delivery systems offers a safer, more effective alternative to conventional antibiotics in treating UTIs.

Conclusion: The integration of nanotechnology and herbal therapies revolutionizes UTI management through precision medicine. This approach enhances treatment efficacy, diagnostic accuracy, and patient outcomes, offering a personalized solution to combat antibiotic resistance and urinary tract abnormalities with improved targeting and minimal side effects.

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来源期刊
Current drug targets
Current drug targets 医学-药学
CiteScore
6.20
自引率
0.00%
发文量
127
审稿时长
3-8 weeks
期刊介绍: Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.
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