卡铂负载聚乙二醇化- MWCNTs的口服节律制剂：高效液相色谱方法验证和兔血浆药代动力学研究。

IF 1.8 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current drug metabolism Pub Date : 2025-07-22 DOI:10.2174/0113892002378541250704181148

Suraj Sharma, Ketousetuo Kuotsu, Sweet Naskar

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引用次数: 0

摘要

背景：碳纳米管（CNTs）由于其独特的物理化学性质和生物相容性，已成为一种很有前途的药物递送纳米载体。目的：探讨以碳纳米管为载体的抗肿瘤前药卡铂（CP）口服缓释节律给药制剂的应用前景。方法：使用PubMed和Scopus数据库进行全面的文献综述，涵盖2010年至2024年间发表的研究，重点是基于碳纳米管的药物传递系统及其在癌症治疗中的应用。结果：CNTs在高载药效率、靶向给药、改善药代动力学和提高生物利用度方面具有显著的潜力。一些研究也强调了它们在持续和控制药物释放方面的应用，这对节奏化疗至关重要。结论：基于碳纳米管的给药系统为卡铂口服持续节律制剂的开发提供了一个有前景的平台。然而，在临床转化之前，需要进一步的研究来解决与毒性、生物降解性和监管接受相关的问题。

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Oral Metronomic Formulation of Carboplatin Loaded PEGylated- MWCNTs: HPLC Method Validation and Pharmacokinetic Studies in Rabbit's Plasma.

Background: Carbon nanotubes (CNTs) have emerged as promising nanocarriers in drug delivery due to their unique physicochemical properties and biocompatibility.

Objective: This study aims to explore the potential of oral sustained-release metronomic drug delivery formulations of carboplatin (CP), a widely used antitumor prodrug, utilizing carbon nanotubes as carriers.

Methods: A comprehensive literature review was conducted using PubMed and Scopus databases, covering studies published between the years 2010 and 2024, focusing on CNT-based drug delivery systems and their application in cancer therapeutics.

Results: CNTs have demonstrated significant potential in terms of high drug loading efficiency, targeted drug delivery, improved pharmacokinetics, and enhanced bioavailability. Several studies have also highlighted their utility in sustained and controlled drug release, which is critical for metronomic chemotherapy.

Conclusion: Carbon nanotube-based drug delivery systems represent a promising platform for the development of oral sustained metronomic formulations of carboplatin. However, further research is needed to address concerns related to toxicity, biodegradability, and regulatory acceptance before clinical translation.

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来源期刊

Current drug metabolism 医学-生化与分子生物学

CiteScore

4.30

自引率

4.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism. More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.