Sex-specific adverse effects of lipid accumulation products and cardiometabolic indices on the prevalence of gallstones: insights from the 2017-2020 national health and nutrition examination survey.

Background: Anthropometric measurements and lipid profiles are associated with the onset of gallstone disease, with these associations exhibiting sex-specific variations. This study investigated the association between the prevalence of gallstones and two anthropometric-lipid markers, namely Lipid Accumulation Products (LAP) and Cardiometabolic Index (CMI), while also assessing the presence of sex disparities.

Methods: Data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES) were analyzed, including 3,541 participants aged 20 years or older with complete information. Weighted logistic regression, restricted cubic spline modeling, and subgroup analyses were employed to assess the relationship between LAP and CMI and gallstone disease, as well as to investigate potential sex-specific differences. An analysis of the receiver operating characteristic (ROC) curve was performed to assess the prediction accuracy of indices and to determine appropriate cutoff values.

Results: Elevated LAP and CMI were significantly correlated with an increased prevalence of gallstone disease among women, whereas no significant association was found in men. For each unit increase in log2-LAP, the multivariable-adjusted odds ratio (OR) for gallstone disease was 1.375 (95% CI: 1.143-1.655). For each 1-point increase in CMI, the multivariable-adjusted OR was 1.408 (95% CI: 1.098-1.806). Quartile analysis demonstrated that higher levels of LAP and CMI were significantly associated with an increased prevalence of gallstones. The associations between CMI, LAP, and the prevalence of gallstones were consistent across all subgroups (p for interaction > 0.05). LAP exhibiting the largest AUC, demonstrating high accuracy in screening for high-risk individuals for gallstone disease, comparable to traditional indices.

Conclusions: The study revealed a positive association between LAP, CMI, and the prevalence of gallstones, observed exclusively among women. The findings suggest that prioritizing the reduction of LAP and CMI is crucial for preventing gallstone disease in women.