Rameez Qasim, Laraib Anmol, Izza Shakeel, Bakhtawar Haseeb, Hurmat Fatima Bhatti, Uzair Iqbal, Shaheer Ahmad, Muhammad Hassan, Mubashir Raza
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引用次数: 0
摘要
异柠檬酸脱氢酶1 (IDH1)突变因其与恶性肿瘤(包括胆管癌和急性髓系白血病)的关联而引起关注。Ivosidenib是一种IDH1突变抑制剂,可抑制肿瘤代谢物D-2-HG的形成,恢复正常的细胞更新并抑制肿瘤发生。2024年7月,使用PubMed、Cochrane Library和Embase数据库进行文献检索。研究使用95%置信区间(ci)来显示ivosidenib的安全性和有效性。遵循系统评价和元分析流程指南的首选报告项目。纳入4篇文章,涉及533例患者。对照组的客观缓解率(ORR)和无进展生存期(PFS)显著改善,风险比为0.79,95% CI: 0.71-0.89, Z = 4.05, PFS的P值小于0.001,优势比为0.45,95% CI: 0.30-0.68, Z值为3.86,ORR的P值为0.001。安全概况是有利的。组内总生存率(OS)无显著变化,P值为0.78,风险比为0.98,95% CI: 0.83 ~ 1.15, Z = 0.27。Ivosidenib表现出PFS优势和改善的ORR,具有良好的安全性,但对OS没有影响。有证据表明其作为辅助治疗在临床应用的可行性。
Safety and efficacy of ivosidenib in the treatment of isocitrate dehydrogenase 1 mutant cholangiocarcinoma and acute myeloid leukemia: a systematic review and meta-analysis.
Isocitrate dehydrogenase 1 (IDH1) mutations have gained interest because of their association with malignancies, including cholangiocarcinoma and acute myeloid leukemia. Ivosidenib, an inhibitor of IDH1 mutations, inhibits the formation of the oncometabolite D-2-HG, restoring normal cellular turnover and inhibiting tumorigenesis. In July 2024, a literature search was done using these databases: PubMed, Cochrane Library, and Embase. Studies were to show the safety and efficacy of ivosidenib using 95% confidence intervals (CIs). Preferred Reporting Items for Systematic reviews and Meta-Analyses flow guidelines were followed. Four articles involving 533 patients were included. The objective response rate (ORR) and progression-free survival (PFS) were significantly improved in the control group where risk ratio was 0.79, 95% CI: 0.71-0.89, Z = 4.05, a P value less than 0.001 for PFS, and odds ratio was 0.45, 95% CI: 0.30-0.68, Z value of 3.86, and P = 0.001 for ORR. The safety profile was favorable. Overall survival (OS) did not change significantly within the groups, as indicated by a P value of 0.78, risk ratio of 0.98, 95% CI: 0.83-1.15, and Z = 0.27. Ivosidenib demonstrated a PFS advantage and improved ORR with a favorable safety profile, but no effect on the OS. Evidence is suggestive of its plausibility for clinical usage as an adjunct therapy.
期刊介绍:
Anti-Cancer Drugs reports both clinical and experimental results related to anti-cancer drugs, and welcomes contributions on anti-cancer drug design, drug delivery, pharmacology, hormonal and biological modalities and chemotherapy evaluation. An internationally refereed journal devoted to the fast publication of innovative investigations on therapeutic agents against cancer, Anti-Cancer Drugs aims to stimulate and report research on both toxic and non-toxic anti-cancer agents. Consequently, the scope on the journal will cover both conventional cytotoxic chemotherapy and hormonal or biological response modalities such as interleukins and immunotherapy. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.