高强度间歇训练通过增强骨钙素驱动的星形胶质细胞BDNF表达和刺激海马神经发生改善肥胖小鼠的记忆缺陷。

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Hyukki Chang, Yea-Hyun Leem, Jonghoon Park, Jung-Eun Park, Soo Jin Yang, Hee-Sun Kim
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引用次数: 0

摘要

肥胖会导致认知障碍,尤其是记忆障碍。体育锻炼是加强体重管理和促进大脑健康的一种非药物方法。特别是,高强度间歇训练(HIIT)的效果与传统有氧运动相当,甚至超过传统有氧运动。然而,其益智作用和潜在机制尚不清楚。本研究旨在探讨高热量饮食诱导的神经毒性背景下,高强度间歇训练(HIIT)的认知增强作用,特别强调骨钙素(OCN)/GPR158信号在成人海马神经发生中的作用。小鼠喂食高脂高糖饮食(HFHSD) 12周。然后,他们参加了一个为期8周的HIIT项目,训练强度是根据他们预先评估的最大跑步能力(MRC)来确定的。HIIT有效调节体重和摄食行为,同时改善MRC。改良的y迷宫实验表明,它还通过促进主要位于海马背侧的成年海马神经发生,改善hfhsd诱导的记忆缺陷。此外,HIIT显著增加星形胶质细胞OCN/GPR158信号通路,显著升高齿状回星形胶质细胞BDNF表达。ocn阳性星形胶质细胞中也检测到AKT/GSK3β通路的激活。本研究共同提出了hiit特异性机制,表明星形细胞OCN/GPR158可能通过其前神经源性作用显著促进hfhsd喂养小鼠的记忆改善。因此,HIIT可以作为对抗与代谢紊乱相关的认知能力下降的有效策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-Intensity Interval Training Improves Memory Deficits in Obese Mice by Enhancing Osteocalcin-Driven Astrocytic BDNF Expression and Stimulating Hippocampal Neurogenesis

Obesity contributes to cognitive disorders, particularly memory impairment. Physical exercise is a non-pharmacological approach for enhancing weight management and promoting brain health. Especially, high-intensity interval training (HIIT) yields results comparable to or even exceeding those of traditional aerobic exercises. However, its nootropic effects and underlying mechanisms remain unclear. This study aims to investigate the cognitive-enhancing effects of high-intensity interval training (HIIT) in the context of neurotoxicity induced by a high-calorie diet, with particular emphasis on the role of osteocalcin (OCN)/GPR158 signaling in adult hippocampal neurogenesis. Mice were fed a high-fat, high-sucrose diet (HFHSD) for 12 weeks. They then participated in an 8-week HIIT program, with the training intensity determined based on their pre-assessed maximal running capacity (MRC). HIIT efficiently regulated body weight and feeding behavior while improving MRC. It also ameliorated HFHSD-induced memory deficits, as demonstrated by the modified Y-maze test, by promoting adult hippocampal neurogenesis, which was primarily localized to the dorsal hippocampus. Moreover, HIIT markedly increased astrocytic OCN/GPR158 signaling and significantly elevated BDNF expression in astrocytes within the dentate gyrus. Activation of the AKT/GSK3β pathway was also detected in OCN-positive astrocytes. This study collectively suggests a HIIT-specific mechanism, indicating that astrocytic OCN/GPR158 may contribute significantly to memory improvement in HFHSD-fed mice through its proneurogenic effects. Therefore, HIIT could serve as an effective strategy for combating the cognitive decline associated with metabolic disorders.

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来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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