超低成本胰岛素泵输注糖尿病大鼠控制血糖水平的研究。

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Jhon E. Goez-Mora MSc, Natalia Arbelaez-Córdoba MSc, Norman Balcazar-Morales PhD, Pablo S. Rivadeneira PhD
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引用次数: 0

摘要

本研究评估了用于调节血糖的超低成本胰岛素泵的准确性,胰岛素泵是人工胰腺的重要组成部分。目的:主要目的是评估使用超低成本胰岛素泵与胰岛素注射的血糖调节的准确性。方法:采用链脲佐菌素诱导14只14周龄雄性Wistar大鼠进行实验。对照组(7例)采用皮下注射胰岛素治疗,研究组(7例)采用实验性胰岛素泵治疗。结果:我们的研究结果表明,超低成本胰岛素泵在血糖调节方面的表现与使用标准临床胰岛素治疗的胰岛素注射相当。通过CGM获得的血糖记录表明,两种方法的趋势一致,血糖中位数绝对相对差为6.1748 mg/dL,四分位数间差为14.57 mg/dL。在测试0.09至2.06 U的不同胰岛素单位时,达到70至180 mg/dL的葡萄糖水平的反应时间约为55分钟。系统检测到4例阻塞,平均时间为3 s,符合EN60601-2-24标准。结论:通过对糖尿病大鼠和超低成本胰岛素泵的体内实验证明,该胰岛素泵原型可用于临床试验中的血糖调节,且符合EN60601-2-24标准。未来的工作应该集中在进行胰岛素泵闭环测试和网络安全研究,以防止任何可能的外部攻击。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Study of insulin infusion in diabetic rats with an ultra-low-cost insulin pump for managing blood glucose levels

Study of insulin infusion in diabetic rats with an ultra-low-cost insulin pump for managing blood glucose levels

Introduction

This study assesses the accuracy of an ultra-low-cost insulin pump for regulating blood glucose, an essential component of the artificial pancreas.

Objectives

The primary objective is to assess the accuracy of blood glucose regulation using an ultra-low-cost insulin pump compared with insulin injections.

Methods

The study was conducted using 14 male Wistar rats aged 14 weeks, which were induced with diabetes through a streptozotocin procedure. The control group (seven subjects) was treated with subcutaneous insulin injections, and the study group (seven subjects) was treated with the experimental insulin pump.

Results

Our findings reveal that the ultra-low-cost insulin pump performs comparably to insulin injections for glycemia regulation using standard clinical insulin treatment. The blood glucose records obtained by CGM indicate that trends in both methods correspond, with a glycemia median absolute relative difference of 6.1748 mg/dL and an interquartile range of 14.57 mg/dL. The response time to reach glucose levels between 70 and 180 mg/dL was around 55 min, testing different amounts of insulin units ranging from 0.09 to 2.06 U. Also, four obstruction cases were detected by the system in an average time of 3 s, showing compliance with the EN60601-2-24 standard.

Conclusions

The in vivo experiments with diabetic rats and ultra-low-cost insulin pumps demonstrate that these prototypes can be used for glucose regulation in clinical trials while complying with the conditions of the EN60601-2-24 standard. Future work should focus on conducting insulin pump tests in a closed loop and a cybersecurity study to prevent any possible external attack.

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来源期刊
Journal of Diabetes Investigation
Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
9.40%
发文量
218
审稿时长
6-12 weeks
期刊介绍: Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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