钯催化底物控制的宝石-二氟烯的区域发散型氢胺化反应。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-22 DOI:10.1021/acs.orglett.5c02471

Bao-Xin Liu, Shi-Cun Li, Han-Wen Rao, Qian-Qian Yang*, Wei Du* and Ying-Chun Chen*,

引用次数: 0

摘要

我们报道钯催化的宝石-二氟烯的区域发散性氢胺化反应。使用吲哚作为亲核试剂可生成富集对映体的γ加成产物，而使用2-吲哚羧酸型底物可改变选择性，只产生β加成e-烯烃。该协议提供了有效的访问各种二氟烷基吲哚衍生物，显示出大量的底物范围和广泛的官能团兼容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-Catalyzed Substrate-Controlled Regiodivergent Hydroamination of gem-Difluoroallenes

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Palladium-Catalyzed Substrate-Controlled Regiodivergent Hydroamination of gem-Difluoroallenes

We report palladium-catalyzed regiodivergent hydroamination reactions of gem-difluoroallenes. Employing indolines as the nucleophiles leads to the formation of enantioenriched γ-addition products, while the use of 2-indole-carboxylate-type substrates switches the selectivity, delivering β-addition E-alkenes exclusively. This protocol provides efficient access to diverse difluoroalkylated indole derivatives, showing substantial substrate scope and broad functional group compatibility.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.