手术诱导的炎症减少与肥胖患者神经抑制控制的改善有关。

IF 7.6 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2025-07-19 DOI:10.1016/j.bbi.2025.07.012

Lisa-Katrin Kaufmann , Emma Custers , Debby Vreeken , Jessica Snabel , Martine C. Morrison , Robert Kleemann , Maximilian Wiesmann , Eric J. Hazebroek , Esther Aarts , Amanda J. Kiliaan

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引用次数: 0

摘要

肥胖与抑制控制受损和低度全身性炎症有关。全身性炎症对神经认知表现有不利影响。在这里，我们研究了代谢减肥手术对全身性炎症的影响及其对抑制控制的神经机制的影响。在47名严重肥胖患者的样本中，我们通过fMRI Stroop任务探测神经激活和连接，评估了减肥手术前和手术后2 年的抑制控制加工。我们研究了手术引起的全身性炎症血浆标志物的改变是否与神经反应改变有关。数据收集作为BARICO（肥胖手术Rijnstate和Radboudumc神经成像和认知）研究的一部分。纵向分析显示，手术后尾状核和左岛的stroop相关激活减少。这些激活变化伴随着与内侧上额叶区功能耦合的炎症相关变化。具体来说，术后瘦素（促炎）的大幅下降与脑岛前部和内侧额上回之间的连通性下降有关，而巨噬细胞迁移抑制因子（MIF，潜在的神经保护作用）的增加与尾状核和内侧额上回之间的连通性增强有关。重要的是，尾状核和内侧额上回之间功能耦合的改善预示着更好的任务表现。我们的研究结果表明，手术诱导的全身性炎症的减少可能通过促进炎症敏感大脑区域的神经变化及其功能相互作用来改善肥胖个体的抑制性控制。该方案已前瞻性地在荷兰审判登记处Onderzoekmetmensen登记。n1，试用号NTR29050。

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Surgery-induced reduction in inflammation relates to improved neural inhibitory control in obesity

Obesity is associated with impaired inhibitory control and low-grade systemic inflammation. Systemic inflammation adversely affects neurocognitive performance. Here, we investigate the effects of metabolic bariatric surgery on systemic inflammation and its influence on neural mechanisms underlying inhibitory control. In a sample of 47 individuals with severe obesity, we assessed inhibitory control processing pre- and 2 years post-bariatric surgery by probing neural activation and connectivity during an fMRI Stroop task. We investigated whether surgery-induced changes in plasma markers of systemic inflammation were related to changes in altered neural responses. Data were collected as part of the BARICO (Bariatric surgery Rijnstate and Radboudumc neuroimaging and Cognition in Obesity) study. Longitudinal analyses revealed decreased Stroop-related activation in the caudate nucleus and the left insula following surgery. These activation changes were accompanied by inflammation-related changes in functional coupling with medial superior frontal regions. Specifically, greater post-surgery decreases in leptin (pro-inflammatory) were associated with decreased connectivity between the anterior insula and the medial superior frontal regions, while increases in macrophage migration inhibitory factor (MIF, potentially neuroprotective) were linked to enhanced connectivity between the caudate nucleus and the medial superior frontal gyrus. Importantly, improved functional coupling between the caudate nucleus and the medial superior frontal gyrus was predictive of better task performance. Our findings suggest that surgery-induced reductions in systemic inflammation may improve inhibitory control in individuals with obesity by promoting neural changes in inflammation-sensitive brain regions and their functional interactions.

This protocol was prospectively registered with the Dutch Trial Register Onderzoekmetmensen.nl, with trial number NTR29050.

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.