fontan手术患者脾脏形态变化的纵向分析

Q1 Medicine

Informatics in Medicine Unlocked Pub Date : 2025-01-01 DOI:10.1016/j.imu.2025.101665

Varatharajan Nainamalai , Håvard Bjørke Jenssen , Mostafa Rezaeitaleshmahalleh , Djinaud Prophete , Jordan Gosnell , Sarah Khan , Marcus Haw , Jingfeng Jiang , Joseph Vettukattil

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引用次数: 0

摘要

背景：脾大小可作为预测Fontan相关性肝病（FALD）患者门静脉高压和肝脏异常的替代生物标志物。我们利用放射学特征的形态学特征分析了FALD受试者脾脏的长期形状变化。方法：我们使用36例行3期Fontan手术的患者的154张图像（84张来自计算机断层扫描，70张来自磁共振成像）和对照组的145张计算机断层扫描图像来评估脾肿大。为了了解脾肿大，我们分析了三个10年间隔的13个脾脏形状特征，以及对照组和FALD受试者之间的差异。结果术后各时间段均可见脾脏肿大。同时，显著性差异(显著水平α = 0.05, p <；对照组与Fontan相关性肝病患者的形态特征之间存在α)。结论Fontan 3期矫正后的形态学特征与对照组有明显区别。

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A longitudinal analysis of morphological shape variation of spleen in patients with fontan surgery

Background

Splenic size serves as a surrogate biomarker for predicting portal vein hyper-tension and liver abnormalities in subjects with Fontan Associated Liver Disease (FALD). We analyze the long-term shape variation of the spleen in FALD subjects using morphological shape features of radiomic features.

Methods

We used 154 (84 from computed tomography and 70 from magnetic resonance) image volumes obtained from 36 individuals who underwent stage 3 Fontan procedure and 145 computed tomography images from controls to assess splenomegaly. To understand the splenomegaly, thirteen shape features of the spleen over three 10-year intervals, and variations between controls and FALD subjects were analyzed.

Results

The spleen enlargement was observed in all intervals of the post-surgery period. Also, a significant difference (level of significance α = 0.05, p < α) was observed between the morphological shape features of controls and the Fontan Associated Liver Disease subjects.

Conclusion

Morphological shape features clearly distinguish between controls and subjects after Fontan stage 3 correction.

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来源期刊

Informatics in Medicine Unlocked Medicine-Health Informatics

CiteScore

9.50

自引率

0.00%

发文量

282

审稿时长

39 days

期刊介绍： Informatics in Medicine Unlocked (IMU) is an international gold open access journal covering a broad spectrum of topics within medical informatics, including (but not limited to) papers focusing on imaging, pathology, teledermatology, public health, ophthalmological, nursing and translational medicine informatics. The full papers that are published in the journal are accessible to all who visit the website.