β-碳胺在抗癌药物发现中的优势支架研究进展（2019-2024）

IF 3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry Pub Date : 2025-07-20 DOI:10.1016/j.bmc.2025.118325

Fuqiang Yu , Shutang Li , Baohu Li , Peng Zhan , Xujie Wang , Jinfei Yang

{"title":"β-碳胺在抗癌药物发现中的优势支架研究进展（2019-2024）","authors":"Fuqiang Yu , Shutang Li , Baohu Li , Peng Zhan , Xujie Wang , Jinfei Yang","doi":"10.1016/j.bmc.2025.118325","DOIUrl":null,"url":null,"abstract":"<div><div>Cancer remains a formidable global health challenge, driving the need for targeted therapeutic agents to improve clinical outcomes. Natural and synthetic β-carboline alkaloids, characterized by their indole-based heterocyclic structures, have emerged as privileged scaffolds in oncology drug development due to their multimodal antitumor mechanisms. This review systematically evaluates recent advancements in β-carboline derivatives research, with emphasis on structural modification strategies, structure-activity relationships, and mechanistic elucidation of tumor suppression pathways. Through multidimensional evaluation and analysis, we propose actionable directions for the development of β-carboline derivatives with enhanced pharmacological profiles for treating various cancers.</div></div>","PeriodicalId":255,"journal":{"name":"Bioorganic & Medicinal Chemistry","volume":"129 ","pages":"Article 118325"},"PeriodicalIF":3.0000,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent research progress of β-carbolines as privileged scaffold in the discovery of anticancer agent (2019–2024)\",\"authors\":\"Fuqiang Yu , Shutang Li , Baohu Li , Peng Zhan , Xujie Wang , Jinfei Yang\",\"doi\":\"10.1016/j.bmc.2025.118325\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Cancer remains a formidable global health challenge, driving the need for targeted therapeutic agents to improve clinical outcomes. Natural and synthetic β-carboline alkaloids, characterized by their indole-based heterocyclic structures, have emerged as privileged scaffolds in oncology drug development due to their multimodal antitumor mechanisms. This review systematically evaluates recent advancements in β-carboline derivatives research, with emphasis on structural modification strategies, structure-activity relationships, and mechanistic elucidation of tumor suppression pathways. Through multidimensional evaluation and analysis, we propose actionable directions for the development of β-carboline derivatives with enhanced pharmacological profiles for treating various cancers.</div></div>\",\"PeriodicalId\":255,\"journal\":{\"name\":\"Bioorganic & Medicinal Chemistry\",\"volume\":\"129 \",\"pages\":\"Article 118325\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-07-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioorganic & Medicinal Chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0968089625002664\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioorganic & Medicinal Chemistry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0968089625002664","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

癌症仍然是一个巨大的全球健康挑战，推动了对靶向治疗药物的需求，以改善临床结果。天然和合成的β-碳碱生物碱以其吲哚基杂环结构为特征，由于其多模态抗肿瘤机制，已成为肿瘤药物开发的优越支架。本文综述了近年来β-卡波林衍生物的研究进展，重点介绍了β-卡波林衍生物的结构修饰策略、构效关系和抑瘤途径的机制阐明。通过多维度的评估和分析，我们为开发具有增强药理特征的β-卡波林衍生物提供了可行的方向，用于治疗各种癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent research progress of β-carbolines as privileged scaffold in the discovery of anticancer agent (2019–2024)

查看原文本刊更多论文

Recent research progress of β-carbolines as privileged scaffold in the discovery of anticancer agent (2019–2024)

Cancer remains a formidable global health challenge, driving the need for targeted therapeutic agents to improve clinical outcomes. Natural and synthetic β-carboline alkaloids, characterized by their indole-based heterocyclic structures, have emerged as privileged scaffolds in oncology drug development due to their multimodal antitumor mechanisms. This review systematically evaluates recent advancements in β-carboline derivatives research, with emphasis on structural modification strategies, structure-activity relationships, and mechanistic elucidation of tumor suppression pathways. Through multidimensional evaluation and analysis, we propose actionable directions for the development of β-carboline derivatives with enhanced pharmacological profiles for treating various cancers.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Bioorganic & Medicinal Chemistry 医学-生化与分子生物学

CiteScore

6.80

自引率

2.90%

发文量

413

审稿时长

17 days

期刊介绍： Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.