铑催化区域选择性和对映选择性合成共轭炔基胺。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-21 DOI:10.1021/acs.orglett.5c02763

Xiang Li, and , Changkun Li*,

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引用次数: 0

摘要

共轭炔是用途广泛的合成中间体。然而，手性共轭炔的合成仍然具有挑战性。以外消旋磷酸乙烯基和各种胺为原料合成了具有高度区域选择性和对映选择性的共轭乙烯基胺。在Rh配合物的存在下，可获得高达20:1的支线比和99%的ee。手性双恶唑啉膦（NPN*）配体在这一转化过程中起着控制化学和立体化学的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rhodium-Catalyzed Regio- and Enantioselective Synthesis of Conjugated Enynyl Amines

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Rhodium-Catalyzed Regio- and Enantioselective Synthesis of Conjugated Enynyl Amines

Conjugated enynes are versatile synthetic intermediates. However, the synthesis of chiral conjugated enynes is still challenging. A highly regio- and enantioselective synthesis of conjugated enynyl amines from racemic enynyl phosphates and various amines has been developed. Up to 20:1 branch/linear ratio and 99% ee could be obtained in the presence of Rh complexes. The chiral bisoxazolinephosphine (NPN*) ligands play the key role in controlling the chemo- and stereochemistry in this transformation.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.