{"title":"阿尔茨海默病的内质网-线粒体偶联。","authors":"Michela Rossini, Tânia Fernandes, Irene D'Arsiè, Riccardo Filadi","doi":"10.1177/25152564251330069","DOIUrl":null,"url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common neurodegenerative disorder of the elderly and no cure is currently available, as the mechanisms leading to neuronal damage and cognitive impairments remain elusive. In the last years, accumulating evidence highlighted early perturbations of the communication between mitochondria and endoplasmic reticulum (ER) in AD models. In this short review, we summarize recent findings linking alterations of ER-mitochondria coupling with typical AD hallmarks.</p>","PeriodicalId":101304,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":"8 ","pages":"25152564251330069"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271663/pdf/","citationCount":"0","resultStr":"{\"title\":\"Endoplasmic reticulum-Mitochondria Coupling in Alzheimer's Disease.\",\"authors\":\"Michela Rossini, Tânia Fernandes, Irene D'Arsiè, Riccardo Filadi\",\"doi\":\"10.1177/25152564251330069\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Alzheimer's disease (AD) is the most common neurodegenerative disorder of the elderly and no cure is currently available, as the mechanisms leading to neuronal damage and cognitive impairments remain elusive. In the last years, accumulating evidence highlighted early perturbations of the communication between mitochondria and endoplasmic reticulum (ER) in AD models. In this short review, we summarize recent findings linking alterations of ER-mitochondria coupling with typical AD hallmarks.</p>\",\"PeriodicalId\":101304,\"journal\":{\"name\":\"Contact (Thousand Oaks (Ventura County, Calif.))\",\"volume\":\"8 \",\"pages\":\"25152564251330069\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271663/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Contact (Thousand Oaks (Ventura County, Calif.))\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/25152564251330069\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contact (Thousand Oaks (Ventura County, Calif.))","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/25152564251330069","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Endoplasmic reticulum-Mitochondria Coupling in Alzheimer's Disease.
Alzheimer's disease (AD) is the most common neurodegenerative disorder of the elderly and no cure is currently available, as the mechanisms leading to neuronal damage and cognitive impairments remain elusive. In the last years, accumulating evidence highlighted early perturbations of the communication between mitochondria and endoplasmic reticulum (ER) in AD models. In this short review, we summarize recent findings linking alterations of ER-mitochondria coupling with typical AD hallmarks.
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