{"title":"运动单元数索引（MUNIX）在控制儿童：参考值和可靠性。","authors":"Christophe Boulay, Emilien Delmont, Frédérique Audic, Cécile Halbert, Sébastien Pesenti, Brigitte Chabrol, Béatrice Desnous, Shahram Attarian","doi":"10.1002/mus.28470","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction/aims: </strong>The motor unit number index (MUNIX) is recognized as a reliable electrophysiological biomarker, and reference values are available for healthy adults but not for children. The aim of this study was to determine reference MUNIX values in healthy children.</p><p><strong>Methods: </strong>Sixty control children (28 females) were grouped as under 5 years (n<sub>1</sub> = 16), 5-10 years (n<sub>2</sub> = 15), 10-15 years (n<sub>3</sub> = 20), and 15-17 years (n<sub>4</sub> = 9). MUNIX measurements were performed by an experienced and an inexperienced investigator in the abductor digiti minimi (ADM) and abductor pollicis brevis (APB) on both sides when possible.</p><p><strong>Results: </strong>The APB MUNIX increased by 6.5 [95% confidence interval, 3.2-9.7] per year of age, 1.0 [0.5-1.5] per cm, and 1.7 [0.4-4.0] per kg (p < 0.001 in each case), but was not independently associated with either of these three variables in multivariable analysis. The APB compound muscle action potential (CMAP) increased by 0.42 [0.30-0.52] per year of age, 0.06 [0.04-0.08] per cm, and 0.11 [0.07-0.14] per kg (p < 0.001 in each case), and increased with age independently of height and weight at borderline significance (p = 0.065). Measurement reproducibility was high for the experienced investigator, but lower between the experienced and the inexperienced investigator.</p><p><strong>Discussion: </strong>The high intra-investigator reproducibility for the experienced investigator indicates that these parameters are useful electrophysiological biomarkers for disease progression and potential treatment response.</p>","PeriodicalId":18968,"journal":{"name":"Muscle & Nerve","volume":" ","pages":"625-631"},"PeriodicalIF":3.1000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435161/pdf/","citationCount":"0","resultStr":"{\"title\":\"Motor Unit Number Index (MUNIX) in Control Children: Reference Values and Reliability.\",\"authors\":\"Christophe Boulay, Emilien Delmont, Frédérique Audic, Cécile Halbert, Sébastien Pesenti, Brigitte Chabrol, Béatrice Desnous, Shahram Attarian\",\"doi\":\"10.1002/mus.28470\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction/aims: </strong>The motor unit number index (MUNIX) is recognized as a reliable electrophysiological biomarker, and reference values are available for healthy adults but not for children. The aim of this study was to determine reference MUNIX values in healthy children.</p><p><strong>Methods: </strong>Sixty control children (28 females) were grouped as under 5 years (n<sub>1</sub> = 16), 5-10 years (n<sub>2</sub> = 15), 10-15 years (n<sub>3</sub> = 20), and 15-17 years (n<sub>4</sub> = 9). MUNIX measurements were performed by an experienced and an inexperienced investigator in the abductor digiti minimi (ADM) and abductor pollicis brevis (APB) on both sides when possible.</p><p><strong>Results: </strong>The APB MUNIX increased by 6.5 [95% confidence interval, 3.2-9.7] per year of age, 1.0 [0.5-1.5] per cm, and 1.7 [0.4-4.0] per kg (p < 0.001 in each case), but was not independently associated with either of these three variables in multivariable analysis. The APB compound muscle action potential (CMAP) increased by 0.42 [0.30-0.52] per year of age, 0.06 [0.04-0.08] per cm, and 0.11 [0.07-0.14] per kg (p < 0.001 in each case), and increased with age independently of height and weight at borderline significance (p = 0.065). Measurement reproducibility was high for the experienced investigator, but lower between the experienced and the inexperienced investigator.</p><p><strong>Discussion: </strong>The high intra-investigator reproducibility for the experienced investigator indicates that these parameters are useful electrophysiological biomarkers for disease progression and potential treatment response.</p>\",\"PeriodicalId\":18968,\"journal\":{\"name\":\"Muscle & Nerve\",\"volume\":\" \",\"pages\":\"625-631\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435161/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Muscle & Nerve\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/mus.28470\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Muscle & Nerve","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/mus.28470","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/21 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
简介/目的：运动单元数指数（motor unit number index， MUNIX）是公认的可靠的电生理生物标志物，对健康成人有参考值，但对儿童没有参考值。本研究的目的是确定健康儿童的参考值。方法：对照组儿童60例（女性28例），分为5岁以下（n1 = 16）、5 ~ 10岁（n2 = 15）、10 ~ 15岁（n3 = 20）、15 ~ 17岁（n4 = 9）。在可能的情况下，由一名经验丰富的调查员和一名经验不足的调查员对两侧的小指外展肌（ADM）和短掌外展肌（APB）进行mmx测量。结果：APB的MUNIX增加了6.5[95%置信区间，3.2-9.7]/岁，1.0 [0.5-1.5]/ cm, 1.7 [0.4-4.0] / kg (p)。讨论：研究人员内部的高重复性表明，这些参数是疾病进展和潜在治疗反应的有用电生理生物标志物。
Motor Unit Number Index (MUNIX) in Control Children: Reference Values and Reliability.
Introduction/aims: The motor unit number index (MUNIX) is recognized as a reliable electrophysiological biomarker, and reference values are available for healthy adults but not for children. The aim of this study was to determine reference MUNIX values in healthy children.
Methods: Sixty control children (28 females) were grouped as under 5 years (n1 = 16), 5-10 years (n2 = 15), 10-15 years (n3 = 20), and 15-17 years (n4 = 9). MUNIX measurements were performed by an experienced and an inexperienced investigator in the abductor digiti minimi (ADM) and abductor pollicis brevis (APB) on both sides when possible.
Results: The APB MUNIX increased by 6.5 [95% confidence interval, 3.2-9.7] per year of age, 1.0 [0.5-1.5] per cm, and 1.7 [0.4-4.0] per kg (p < 0.001 in each case), but was not independently associated with either of these three variables in multivariable analysis. The APB compound muscle action potential (CMAP) increased by 0.42 [0.30-0.52] per year of age, 0.06 [0.04-0.08] per cm, and 0.11 [0.07-0.14] per kg (p < 0.001 in each case), and increased with age independently of height and weight at borderline significance (p = 0.065). Measurement reproducibility was high for the experienced investigator, but lower between the experienced and the inexperienced investigator.
Discussion: The high intra-investigator reproducibility for the experienced investigator indicates that these parameters are useful electrophysiological biomarkers for disease progression and potential treatment response.
期刊介绍：
Muscle & Nerve is an international and interdisciplinary publication of original contributions, in both health and disease, concerning studies of the muscle, the neuromuscular junction, the peripheral motor, sensory and autonomic neurons, and the central nervous system where the behavior of the peripheral nervous system is clarified. Appearing monthly, Muscle & Nerve publishes clinical studies and clinically relevant research reports in the fields of anatomy, biochemistry, cell biology, electrophysiology and electrodiagnosis, epidemiology, genetics, immunology, pathology, pharmacology, physiology, toxicology, and virology. The Journal welcomes articles and reports on basic clinical electrophysiology and electrodiagnosis. We expedite some papers dealing with timely topics to keep up with the fast-moving pace of science, based on the referees'' recommendation.
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