LONP1缺失导致β细胞线粒体混乱

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-07-21 DOI:10.1038/s42255-025-01328-4

Kok Lim Kua, Carmella Evans-Molina

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引用次数: 0

摘要

在本期Nature Metabolism杂志上，Li等人发现线粒体蛋白折叠的中断是2型糖尿病中β细胞功能障碍的早期触发因素，并强调LONP1在维持线粒体蛋白平衡中起关键作用。提高线粒体蛋白折叠能力可能为保护β细胞和预防或延缓糖尿病提供了一种有希望的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

LONP1 loss causes mitochondrial mayhem in β-cells

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LONP1 loss causes mitochondrial mayhem in β-cells

In this issue of Nature Metabolism, Li et al. reveal that disruptions in mitochondrial protein folding are an early trigger of β-cell dysfunction in type 2 diabetes and highlight that LONP1 has a key role in the maintenance of mitochondrial proteostasis. Boosting mitochondrial protein folding capacity may offer a promising strategy to protect β-cells and prevent or delay diabetes.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.