微波辐射诱导大鼠BDNF Val76Met多态性与认知功能改变易感性的相关性研究

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Mingzhao Zhang, Yang Wang, Yong Zou, Weijia Zhi, Xuelong Zhao, Jiajia Niu, Lina Du, Lizhen Ma, Lifeng Wang
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引用次数: 0

摘要

微波辐射对大脑非常敏感,在动物模型中已经显示出对记忆和学习的影响。脑源性神经营养因子(brain -derived neurotrophic factor, BDNF)在神经功能和大脑发育中起着至关重要的作用,其基因存在许多单核苷酸多态性。一些神经病理疾病与BDNF Val66Met变异有关。在本研究中,我们使用CRISPR技术在大鼠中创建了BDNF Val76Met突变。然后将大鼠分别置于x波段和s波段微波辐射下,平均功率密度为50 mW/cm²,每天15分钟,持续5天。我们评估了大鼠的认知能力,并研究了脑内神经结构和BDNF mRNA水平。我们发现BDNF Val76Met大鼠的学习能力受损,大脑结构改变,BDNF mRNA减少。同时,我们发现在50mW/cm2的微波辐射下,BDNF Val76Met大鼠的脑结构和功能性损伤加重,并且由于s波段微波比x波段微波穿透性更强,对s波段微波的敏感性更高。考虑到动物和人类之间的遗传差异,需要更多的研究来确定这个SNP位置影响微波辐射引起的认知变化的确切机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research on the Correlation between BDNF Val76Met Polymorphism and Susceptibility to Changes of Cognitive Function in Rats Induced by Microwave Radiation

Microwave radiation is extremely sensitive to the brain and has been shown in animal models to affect memory and learning. Brain-derived neurotrophic factor (BDNF) is essential for neural function and brain development, with many single nucleotide polymorphisms (SNPs) in gene. Several neuropathological disorders have been linked to the BDNF Val66Met variation. Using CRISPR, we created BDNF Val76Met mutations in rats in this study. The rats were then subjected to X-band and S-band microwave radiation, respectively, at an average power density of 50 mW/cm² for 15 min every day for five days. We assessed cognitive capacity and investigated the neural structure and BDNF mRNA levels in the brain of rats. We discovered that BDNF Val76Met rats had impaired learning capacity and altered brain structure, with a decrease in BDNF mRNA. Meanwhile, we found that BDNF Val76Met rats exhibited aggravated structural and functional brain damage under 50mW/cm2 microwave radiation, and showed higher sensitivity to S-band microwave due to the stronger penetration compared to X-band microwaves. Considering the genetic differences between animals and humans, more research is needed to determine the exact mechanism by which this SNP location affects cognitive changes caused by microwave radiation.

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来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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