供电子硼水杨基腙作为脂滴成像的双态发射荧光团。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-18 DOI:10.1021/acs.orglett.5c02473

Lei Wang, Yingzhu Sun, Changjiang Yu*, Wenlong Ma, Yingjian Shang, Ling Ding, Ting Wang, Xing Guo, Jiawen Zhang, Yang Li*, Erhong Hao, Guan-Wu Wang* and Lijuan Jiao*,

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引用次数: 0

摘要

我们报道了一类新的给电子硼螯合水杨基腙（BOSHY）荧光团通过有效的“两步，一锅”缩合策略合成。这些结构多样的染料在刚性的6,7-熔合双环结构中包含一个立体硼中心，表现出显著的双态发射特性，具有高量子产率（溶液中高达95%，固态中高达74%）和高达7200 cm-1的大斯托克斯位移，以及有希望的热带活性。值得注意的是，选定的BOSHY衍生物在活细胞中显示出出色的脂滴成像特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electron-Donating Boronic Salicylhydrazones as Dual-State Emissive Fluorophores for Lipid Droplet Imaging

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Electron-Donating Boronic Salicylhydrazones as Dual-State Emissive Fluorophores for Lipid Droplet Imaging

We report a novel class of electron-donating boron-chelated salicylhydrazone (BOSHY) fluorophores synthesized through an efficient “two-step, one-pot” condensation strategy. These structurally versatile dyes incorporate a stereogenic boron center within a rigid 6,7-fused bicyclic architecture, demonstrating remarkable dual-state emission characteristics with high quantum yields (up to 95% in solution and 74% in the solid state) and large Stokes shifts up to 7200 cm^–1, along with promising chiroptical activity. Notably, selected BOSHY derivatives display outstanding specificity for lipid droplet imaging in live cells.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.