揭示转移性癌症细胞外囊泡的新见解：从机制到诊断和靶向治疗的旅程。

IF 12.1 1区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Molecular Therapy Pub Date : 2025-07-17 DOI:10.1016/j.ymthe.2025.07.016

Yaoqi Gui,Meixi Peng,Yongxiu Huang,Zhengyu Chen,Jianfeng Chen,Jianwen Xiao,Dan Liu,Yu Hou

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引用次数: 0

摘要

细胞外囊泡在胚胎发育、细胞迁移、肿瘤恶性转化等多种生理病理过程中发挥着不可或缺的作用。肿瘤源性外泌体（TDEs）已成为肿瘤微环境（TME）的关键组成部分，复杂地参与肿瘤生长、血管通透性和转移前生态位（PMN）的形成。因此，tde将生物活性分子封装在其腔内，促进其递送到远处的微环境，并诱导特定细胞类型的重编程以建立pmn。这反过来又赋予癌细胞强大的生长、转移和耐药能力。在这篇综述中，我们整合了目前阐明小ev在癌症进展中的作用的研究，特别关注癌症转移，以及它们的治疗潜力。此外，我们还回顾了基于外泌体的新方法，如单个EV谱分析，旨在为癌症研究、诊断和治疗开辟新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Unveiling New Insights into Extracellular Vesicles in Metastatic Cancer: A Journey from Mechanisms to Diagnostics and Targeted Therapies.

Extracellular vesicles play an indispensable role in a variety of physiological and pathological processes, including embryonic development, cellular migration and malignant transformation of tumors. Tumor-derived exosomes (TDEs) have emerged as a key component of the tumor microenvironment (TME), intricately involved in tumor growth, vascular permeability and pre-metastatic niche (PMN) formation. Consequently, TDEs encapsulate bioactive molecules in their lumen, facilitating their delivery to distant microenvironments and inducing the reprogramming of specific cell types to establish PMNs. This, in turn, endows cancer cells with robust capabilities for growth, metastasis and chemoresistance. In this review, we consolidate current research elucidating the role of small EVs in cancer progression, with a particular focus on cancer metastasis, and their therapeutic potential. In addition, we review novel exosome-based methods, such as single EV profiling, which aim to open new avenues for cancer research, diagnosis and treatment.

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来源期刊

Molecular Therapy 医学-生物工程与应用微生物

CiteScore

19.20

自引率

3.20%

发文量

357

审稿时长

3 months

期刊介绍： Molecular Therapy is the leading journal for research in gene transfer, vector development, stem cell manipulation, and therapeutic interventions. It covers a broad spectrum of topics including genetic and acquired disease correction, vaccine development, pre-clinical validation, safety/efficacy studies, and clinical trials. With a focus on advancing genetics, medicine, and biotechnology, Molecular Therapy publishes peer-reviewed research, reviews, and commentaries to showcase the latest advancements in the field. With an impressive impact factor of 12.4 in 2022, it continues to attract top-tier contributions.