{"title":"原发性脑肿瘤形成的分子驱动因素。","authors":"Hope T Richard","doi":"10.1016/bs.acr.2025.04.006","DOIUrl":null,"url":null,"abstract":"<p><p>Gliomas are a common form of intracranial malignancy in adults with poor overall survival and limited treatment strategies. There is significant genetic heterogeneity in this tumor group with a complex network of signaling that leads to rapid infiltrative growth as well as chemo- and radio-resistance. This chapter will delve into the complex processes and molecular alterations that feed into the formation and growth of these primary brain tumors.</p>","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":"166 ","pages":"1-32"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Molecular drivers in primary brain tumor formation.\",\"authors\":\"Hope T Richard\",\"doi\":\"10.1016/bs.acr.2025.04.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Gliomas are a common form of intracranial malignancy in adults with poor overall survival and limited treatment strategies. There is significant genetic heterogeneity in this tumor group with a complex network of signaling that leads to rapid infiltrative growth as well as chemo- and radio-resistance. This chapter will delve into the complex processes and molecular alterations that feed into the formation and growth of these primary brain tumors.</p>\",\"PeriodicalId\":94294,\"journal\":{\"name\":\"Advances in cancer research\",\"volume\":\"166 \",\"pages\":\"1-32\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in cancer research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.acr.2025.04.006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in cancer research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/bs.acr.2025.04.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/25 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Molecular drivers in primary brain tumor formation.
Gliomas are a common form of intracranial malignancy in adults with poor overall survival and limited treatment strategies. There is significant genetic heterogeneity in this tumor group with a complex network of signaling that leads to rapid infiltrative growth as well as chemo- and radio-resistance. This chapter will delve into the complex processes and molecular alterations that feed into the formation and growth of these primary brain tumors.
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