Can Gao , Changxu Lu , Jinwen Wei , Zhongyi Mu , Mingli Sun , Dan Dong , Zhenning Liu
{"title":"泛素化:在阿霉素诱导的心脏毒性中一个不可忽略的调节剂。","authors":"Can Gao , Changxu Lu , Jinwen Wei , Zhongyi Mu , Mingli Sun , Dan Dong , Zhenning Liu","doi":"10.1016/j.cbi.2025.111664","DOIUrl":null,"url":null,"abstract":"<div><div>Doxorubicin (DOX), an effective chemotherapeutic drug, is used to alleviate the progression of cancers. However, the cardiotoxic side effects of DOX significantly limit its broader clinical application. Therefore, it is extremely urgent to find effective therapeutic strategies to mitigate doxorubicin-induced cardiotoxicity (DIC). Ubiquitination, a crucial post-translational modification (PTM), is regulated by various ubiquitinases and subsequently marks and modulates the function of proteins. Notably, Numerous studies have found that ubiquitination is closely related to the progression of DIC. However, a comprehensive review of this field remains unreported. Therefore, this review will mainly summarize the critical role of ubiquitination in DIC-associated pathological mechanisms and various potential interventions. Collectively, a comprehensive understanding of ubiquitination in the progression of DIC contributes to providing a crucial theoretical basis and exploring new avenues for the management of DIC.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"419 ","pages":"Article 111664"},"PeriodicalIF":5.4000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ubiquitination: A non-negligible modulator in doxorubicin-induced cardiotoxicity\",\"authors\":\"Can Gao , Changxu Lu , Jinwen Wei , Zhongyi Mu , Mingli Sun , Dan Dong , Zhenning Liu\",\"doi\":\"10.1016/j.cbi.2025.111664\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Doxorubicin (DOX), an effective chemotherapeutic drug, is used to alleviate the progression of cancers. However, the cardiotoxic side effects of DOX significantly limit its broader clinical application. Therefore, it is extremely urgent to find effective therapeutic strategies to mitigate doxorubicin-induced cardiotoxicity (DIC). Ubiquitination, a crucial post-translational modification (PTM), is regulated by various ubiquitinases and subsequently marks and modulates the function of proteins. Notably, Numerous studies have found that ubiquitination is closely related to the progression of DIC. However, a comprehensive review of this field remains unreported. Therefore, this review will mainly summarize the critical role of ubiquitination in DIC-associated pathological mechanisms and various potential interventions. Collectively, a comprehensive understanding of ubiquitination in the progression of DIC contributes to providing a crucial theoretical basis and exploring new avenues for the management of DIC.</div></div>\",\"PeriodicalId\":274,\"journal\":{\"name\":\"Chemico-Biological Interactions\",\"volume\":\"419 \",\"pages\":\"Article 111664\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemico-Biological Interactions\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0009279725002947\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemico-Biological Interactions","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0009279725002947","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Ubiquitination: A non-negligible modulator in doxorubicin-induced cardiotoxicity
Doxorubicin (DOX), an effective chemotherapeutic drug, is used to alleviate the progression of cancers. However, the cardiotoxic side effects of DOX significantly limit its broader clinical application. Therefore, it is extremely urgent to find effective therapeutic strategies to mitigate doxorubicin-induced cardiotoxicity (DIC). Ubiquitination, a crucial post-translational modification (PTM), is regulated by various ubiquitinases and subsequently marks and modulates the function of proteins. Notably, Numerous studies have found that ubiquitination is closely related to the progression of DIC. However, a comprehensive review of this field remains unreported. Therefore, this review will mainly summarize the critical role of ubiquitination in DIC-associated pathological mechanisms and various potential interventions. Collectively, a comprehensive understanding of ubiquitination in the progression of DIC contributes to providing a crucial theoretical basis and exploring new avenues for the management of DIC.
期刊介绍:
Chemico-Biological Interactions publishes research reports and review articles that examine the molecular, cellular, and/or biochemical basis of toxicologically relevant outcomes. Special emphasis is placed on toxicological mechanisms associated with interactions between chemicals and biological systems. Outcomes may include all traditional endpoints caused by synthetic or naturally occurring chemicals, both in vivo and in vitro. Endpoints of interest include, but are not limited to carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.