抗ssa和/或Ro-SSB/La抗体阳性孕妇新生儿狼疮胎儿心脏表现的预测因素

IF 1.2 4区医学 Q3 OBSTETRICS & GYNECOLOGY

American journal of perinatology Pub Date : 2025-07-30 DOI:10.1055/a-2657-6178

Jian Wu, Yanping Ruan, Hairui Wang, Xiaoyan Gu, Jiancheng Han, Yihua He

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引用次数: 0

摘要

目的：抗ssa /Ro和/或SSB/La（抗ssa /SSB）抗体阳性胎儿发生新生儿狼疮（cardiac- nl）心脏表现的相关因素尚不清楚。本研究旨在探讨抗ssa /SSB抗体阳性孕妇胎儿心脏nl的预测因素。研究设计：回顾性纳入669例抗ssa /SSB抗体阳性的孕妇。我们确定胎儿是否有心脏nl并收集相关临床资料。通过单因素和多因素分析来分析胎儿心脏nl与临床特征的相关性。结果：669例抗ssa /SSB抗体检测阳性的孕妇中，发生胎儿心脏nl 26例。单因素分析显示，胎儿心脏- nl与辅助生殖（OR 2.824, P = 0.045）、抗ssa /SSB抗体强阳性（OR 6.437, P < 0.001）、结缔组织病（CTD）临床诊断（OR 4.701, P = 0.037）呈正相关；与羟氯喹（HCQ）（OR 0.187, P < 0.001）、阿司匹林（OR 0.369, P = 0.048）的使用呈负相关。多因素分析显示，辅助生殖（OR 4.110, P = 0.029）、抗ssa /SSB抗体强阳性（OR 8.691, P < 0.001）、CTD临床诊断（OR 8.614, P = 0.010）是胎儿心脏nl的危险因素；HCQ （OR 0.091, P < 0.001）和阿司匹林（OR 0.318, P = 0.035）是胎儿心脏nl的保护因素。结论：本研究确定辅助生殖、抗ssa /SSB抗体强阳性、CTD临床诊断为胎儿心脏nl的独立危险因素。HCQ和阿司匹林的使用是胎儿心脏nl的独立保护因素。

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Predictive Factors of Fetal Cardiac Manifestations of Neonatal Lupus in Anti-SSA/Ro and/or SSB/La Antibody-Positive Pregnant Women.

The factors associated with the development of cardiac manifestations of neonatal lupus (cardiac-NL) in fetuses with positive anti-SSA/Ro and/or SSB/La (anti-SSA/SSB) antibodies are unclear. This study aimed to investigate the predictive factors of fetal cardiac-NL in anti-SSA/SSB antibody-positive pregnant women.A total of 669 pregnant women with positive anti-SSA/SSB antibodies were retrospectively included. We determined whether the fetus had cardiac-NL and collected relevant clinical data. Univariate and multivariate analyses were performed to analyze the correlation between fetal cardiac-NL and clinical characteristics.Among 669 pregnant women with positive anti-SSA/SSB antibody tests, 26 cases of fetal cardiac-NL occurred. Univariate analysis showed that fetal cardiac-NL was positively correlated with the assisted reproduction (odds ratio [OR]: 2.824; p = 0.045), strong positive anti-SSA/SSB antibody (OR: 6.437; p < 0.001), and clinical diagnosis of connective tissue disease (CTD; OR: 4.701; p = 0.037); it was negatively correlated with the use of hydroxychloroquine (HCQ; OR: 0.187; p < 0.001) and aspirin (OR: 0.369; p = 0.048). Multivariate analysis showed that the assisted reproduction (OR: 4.110; p = 0.029), strong positive anti-SSA/SSB antibody (OR: 8.691; p < 0.001), and clinical diagnosis of CTD (OR: 8.614; p = 0.010) were risk factors for fetal cardiac-NL; while HCQ (OR: 0.091; p < 0.001) and aspirin (OR: 0.318; p = 0.035) were protective factors for fetal cardiac-NL.This study determined that assisted reproduction, strong positive anti-SSA/SSB antibody, and clinical diagnosis of CTD are independent risk factors for fetal cardiac-NL. The use of HCQ and aspirin are independent protective factor for fetal cardiac-NL. · Anti-SSA/SSB antibodies can lead to fetal cardiac-NL.. · Assisted reproduction, strong positive anti-SSA/SSB antibodies, and CTD are risk factors.. · HCQ and aspirin use may lower the risk of fetal cardiac-NL..

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来源期刊

American journal of perinatology 医学-妇产科学

CiteScore

5.90

自引率

0.00%

发文量

302

审稿时长

4-8 weeks

期刊介绍： The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields. The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field. All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication. The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.