局部血肿可能是脊柱手术后周围融合的原因

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2025-07-14 DOI:10.1016/j.mehy.2025.111717

Lei Zhou, Yong Tang, Jihong Jiang, Changwei Chen

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引用次数: 0

摘要

脊柱融合术是一种常见的手术，目的是稳定脊柱和减轻与脊柱疾病相关的疼痛。然而，周围融合现象已经被观察到，其中骨桥主要发生在融合部位的周围而不是中心。这一现象引发了人们对导致其发展的因素的质疑。这一假设提出脊柱手术后局部血肿的形成可能是外周融合的重要因素。我们讨论了血肿影响骨形成和融合模式的生物学机制，为进一步研究这一潜在机制提供了科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Local hematoma may be a cause of peripheral fusion after spinal surgery

Spinal fusion surgery is a common procedure aimed at stabilizing the spine and alleviating pain associated with spinal disorders. However, the phenomenon of peripheral fusion has been observed, where bone bridging occurs predominantly at the periphery of the fusion site rather than centrally. This phenomenon raises questions about the factors that contribute to its development. This hypothesis proposes that local hematoma formation after spinal surgery may be a significant contributing factor to peripheral fusion. We discuss the biological mechanisms by which hematoma could influence bone formation and fusion patterns, and provide a scientific basis for further investigation into this potential mechanism.

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.