Shuohan Sun, Dekang Huang, Dan Li, Mochen Jia, Guanying Chen
{"title":"双向热响应工程在第二生物窗口中的高灵敏度镧系元素比率纳米温度计","authors":"Shuohan Sun, Dekang Huang, Dan Li, Mochen Jia, Guanying Chen","doi":"10.1039/d5qi01027f","DOIUrl":null,"url":null,"abstract":"In recent years, lanthanide-doped nanothermometers have made significant progress as non-contact temperature sensing tools in a variety of biological fields. However, limited sucesses has been met in high-sensitivity nanothermometers operating in the second near-infrared (NIR-II) biological window, which can enable sub-centermiter tissue penetration at micrometer-level imaging resolutions. Here, we adopted a core-shell struture to develop a high-sensitivity lanthanide ratiometetric nanothermormeter through bidirectional thermal response of two emissions peak in the NIR-II window. We show that, under 808 nm exciation, the emission intensity at 1330 nm from neodymium ions exhibits a quenching effect, while the one at 1565 nm from erbium ions shows an enhancement at elevated temperatures. This contrasted temeparture dependency endows the nanothermometer to have a high relative sensitivity above 2.3 %°C⁻¹ , with a mxium of 2.5% °C⁻¹, throughout the entire physiological temperature range (30-45 °C). This high-sensitivity nanothermometer enables reliable differenatiaon of temperature differences in both normal and inflamed mice, highlighting its promising uses for in vivo appliations.","PeriodicalId":79,"journal":{"name":"Inorganic Chemistry Frontiers","volume":"677 1","pages":""},"PeriodicalIF":6.1000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High-sensitivity lanthanide ratiometric nanothermometer in the second biological window through bidirectional thermal response engineering\",\"authors\":\"Shuohan Sun, Dekang Huang, Dan Li, Mochen Jia, Guanying Chen\",\"doi\":\"10.1039/d5qi01027f\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In recent years, lanthanide-doped nanothermometers have made significant progress as non-contact temperature sensing tools in a variety of biological fields. However, limited sucesses has been met in high-sensitivity nanothermometers operating in the second near-infrared (NIR-II) biological window, which can enable sub-centermiter tissue penetration at micrometer-level imaging resolutions. Here, we adopted a core-shell struture to develop a high-sensitivity lanthanide ratiometetric nanothermormeter through bidirectional thermal response of two emissions peak in the NIR-II window. We show that, under 808 nm exciation, the emission intensity at 1330 nm from neodymium ions exhibits a quenching effect, while the one at 1565 nm from erbium ions shows an enhancement at elevated temperatures. This contrasted temeparture dependency endows the nanothermometer to have a high relative sensitivity above 2.3 %°C⁻¹ , with a mxium of 2.5% °C⁻¹, throughout the entire physiological temperature range (30-45 °C). This high-sensitivity nanothermometer enables reliable differenatiaon of temperature differences in both normal and inflamed mice, highlighting its promising uses for in vivo appliations.\",\"PeriodicalId\":79,\"journal\":{\"name\":\"Inorganic Chemistry Frontiers\",\"volume\":\"677 1\",\"pages\":\"\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2025-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inorganic Chemistry Frontiers\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d5qi01027f\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5qi01027f","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
High-sensitivity lanthanide ratiometric nanothermometer in the second biological window through bidirectional thermal response engineering
In recent years, lanthanide-doped nanothermometers have made significant progress as non-contact temperature sensing tools in a variety of biological fields. However, limited sucesses has been met in high-sensitivity nanothermometers operating in the second near-infrared (NIR-II) biological window, which can enable sub-centermiter tissue penetration at micrometer-level imaging resolutions. Here, we adopted a core-shell struture to develop a high-sensitivity lanthanide ratiometetric nanothermormeter through bidirectional thermal response of two emissions peak in the NIR-II window. We show that, under 808 nm exciation, the emission intensity at 1330 nm from neodymium ions exhibits a quenching effect, while the one at 1565 nm from erbium ions shows an enhancement at elevated temperatures. This contrasted temeparture dependency endows the nanothermometer to have a high relative sensitivity above 2.3 %°C⁻¹ , with a mxium of 2.5% °C⁻¹, throughout the entire physiological temperature range (30-45 °C). This high-sensitivity nanothermometer enables reliable differenatiaon of temperature differences in both normal and inflamed mice, highlighting its promising uses for in vivo appliations.