Yushu Shao, Yang Zhang, Jiaying Cao, Junyu He, Qian He, Yan Lei, Ning Tang, Yanhong Zhou
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NKp30: A Key Membrane Molecule in the Fight Against Cancer and Infection
Natural killer cells (NK) are crucial components of the immune system. NKp30, a significant activation receptor on the NK cell membrane, plays a cytotoxic role by recognizing and binding to corresponding ligands. This interaction mediates the activation of NK cells and the release of regulatory factors, participating in antitumor and anti-infection processes. This review systematically summarizes the structural features and basic functions of NKp30, the impact of N-terminal glycosylation on NKp30 function, related NKp30 ligands and their roles, as well as the antitumor and anti-infective functions and mechanisms of NKp30. The aim is to provide a new perspective for a comprehensive understanding of NKp30 function.
期刊介绍：
The FASEB Journal publishes international, transdisciplinary research covering all fields of biology at every level of organization: atomic, molecular, cell, tissue, organ, organismic and population. While the journal strives to include research that cuts across the biological sciences, it also considers submissions that lie within one field, but may have implications for other fields as well. The journal seeks to publish basic and translational research, but also welcomes reports of pre-clinical and early clinical research. In addition to research, review, and hypothesis submissions, The FASEB Journal also seeks perspectives, commentaries, book reviews, and similar content related to the life sciences in its Up Front section.
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