n -芳基邻苯酰亚胺在固体氨源转酰胺反应中的化学选择性裂解。

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-17 DOI:10.1021/acs.orglett.5c02420

Julia Urbiña-Alvarez,John Corredor-Barinas,Renata Marcia de Figueiredo,Jean-Marc Campagne,Diego Gamba-Sánchez

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引用次数: 0

摘要

提出了一种利用无毒碳酸铵裂解n -芳基酞酰亚胺的高化学选择性方法。该方法可以回收和再利用保护基团，对n -烷基酞酰亚胺和普通胺保护基团具有完全的选择性，并且对28种底物有效。这种实用的方法允许后期去保护，避免有毒试剂，最大限度地减少浪费，并消除了对色谱的需要，使其成为有机合成中选择性去保护的可持续和有效的替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Chemoselective Cleavage of N-Aryl Phthalimides through a Transamidation Reaction with Solid Sources of Ammonia.

A highly chemoselective method for cleaving N-arylphthalimides using nontoxic ammonium carbonate has been developed. The approach enables recovery and reuse of the protecting group, shows complete selectivity over N-alkylphthalimides and common amine-protecting groups, and is effective across 28 substrates. This practical method allows late-stage deprotection, avoids toxic reagents, minimizes waste, and eliminates the need for chromatography, making it a sustainable and efficient alternative for selective deprotection in organic synthesis.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.