迁徙的基因组足迹：古代DNA如何揭示我们的迁徙历史

IF 10.1 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Genome Biology Pub Date : 2025-07-16 DOI:10.1186/s13059-025-03664-w

Matthew P. Williams, Christian D. Huber

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引用次数: 0

摘要

通过检测混合特征，古代DNA已成为研究人类迁移的有力工具。在这里，我们提出了外加剂分析的理论原理和方法，重点是f统计和qpAdm。我们回顾了文献中的案例研究，展示了这些方法如何揭示人类流动模式，并讨论了与数据质量、人口统计学复杂性和混合和迁移推断的样本代表性相关的挑战。最后，我们强调了混合分析的有希望的进展，并强调了整合遗传，考古和历史数据的重要性，以实现更加跨学科和细致的人类历史重建。

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The genomic footprints of migration: how ancient DNA reveals our history of mobility

Ancient DNA has emerged as a powerful tool for studying human migration through the detection of admixture signatures. Here, we present the theoretical principles and methodologies for admixture analysis, with an emphasis on f-statistics and qpAdm. We review case studies from the literature demonstrating how these methods uncover patterns of human mobility, and discuss challenges related to data quality, demographic complexity, and sample representativeness on admixture and migration inferences. Finally, we highlight promising advancements in admixture analysis and underscore the importance of integrating genetic, archaeological, and historical data to achieve a more interdisciplinary and nuanced reconstruction of human history.

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来源期刊

Genome Biology Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

21.00

自引率

3.30%

发文量

241

审稿时长

2 months

期刊介绍： Genome Biology stands as a premier platform for exceptional research across all domains of biology and biomedicine, explored through a genomic and post-genomic lens. With an impressive impact factor of 12.3 (2022),* the journal secures its position as the 3rd-ranked research journal in the Genetics and Heredity category and the 2nd-ranked research journal in the Biotechnology and Applied Microbiology category by Thomson Reuters. Notably, Genome Biology holds the distinction of being the highest-ranked open-access journal in this category. Our dedicated team of highly trained in-house Editors collaborates closely with our esteemed Editorial Board of international experts, ensuring the journal remains on the forefront of scientific advances and community standards. Regular engagement with researchers at conferences and institute visits underscores our commitment to staying abreast of the latest developments in the field.