Francesca Gasperoni, Christopher H Jackson, Angela M Wood, Michael J Sweeting, Paul J Newcombe, David Stevens, Jessica K Barrett
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Optimal risk-assessment scheduling for primary prevention of cardiovascular disease.
In this work, we introduce a personalized and age-specific net benefit function, composed of benefits and costs, to recommend optimal timing of risk assessments for cardiovascular disease (CVD) prevention. We extend the 2-stage landmarking model to estimate patient-specific CVD risk profiles, adjusting for time-varying covariates. We apply our model to data from the Clinical Practice Research Datalink, comprising primary care electronic health records from the UK. We find that people at lower risk could be recommended an optimal risk-assessment interval of 5 years or more. Time-varying risk factors are required to discriminate between more frequent schedules for high-risk people.
期刊介绍：
Series A (Statistics in Society) publishes high quality papers that demonstrate how statistical thinking, design and analyses play a vital role in all walks of life and benefit society in general. There is no restriction on subject-matter: any interesting, topical and revelatory applications of statistics are welcome. For example, important applications of statistical and related data science methodology in medicine, business and commerce, industry, economics and finance, education and teaching, physical and biomedical sciences, the environment, the law, government and politics, demography, psychology, sociology and sport all fall within the journal''s remit. The journal is therefore aimed at a wide statistical audience and at professional statisticians in particular. Its emphasis is on well-written and clearly reasoned quantitative approaches to problems in the real world rather than the exposition of technical detail. Thus, although the methodological basis of papers must be sound and adequately explained, methodology per se should not be the main focus of a Series A paper. Of particular interest are papers on topical or contentious statistical issues, papers which give reviews or exposés of current statistical concerns and papers which demonstrate how appropriate statistical thinking has contributed to our understanding of important substantive questions. Historical, professional and biographical contributions are also welcome, as are discussions of methods of data collection and of ethical issues, provided that all such papers have substantial statistical relevance.
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