老年患者髋关节置换术后不良后果风险预测模型的建立与验证。

IF 2.8 3区 医学 Q1 Pharmacology, Toxicology and Pharmaceutics
Therapeutics and Clinical Risk Management Pub Date : 2025-07-10 eCollection Date: 2025-01-01 DOI:10.2147/TCRM.S523040
Jie Ding, Guoli Sun, Yifei Ren, Jiajia Xu, Qingqing Hu, Jun Luo, Zhaowen Wu, Ting Chu
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引用次数: 0

摘要

背景:老年患者髋关节置换术后的不良结果经常被观察到;然而,大多数现有研究都集中在单一并发症上。针对更大范围不良后果的综合预测模型仍然不足。本研究探讨了这一问题,并为临床实践提出了新的方法。目的:本研究旨在建立并验证老年患者髋关节置换术后不良后果的风险预测模型。患者和方法:遵循TRIPOD检查表来指导本研究的报告。建模组采用2021年1月1日至2023年12月31日在某三甲医院行髋关节置换术的620例患者的数据。并选择2024年1月1日至2024年12月31日在另一家三级甲等医院骨科住院的264例髋关节置换术后患者作为验证组。通过逻辑回归构建风险预测模型,绘制柱线图,并对其预测效果进行评价。结果:预测模型的影响因素包括年龄、恶性病史、手术方式、白蛋白、凝血酶原时间、ASA分级、手术时间、手术转换状态。Hosmer-Lemeshow检验,χ2=5.418, p=0.712,受试者工作特征曲线下面积(AUC)为0.902。约登指数为0.668,敏感性为0.84,特异性为0.828。实际应用率为83.33%。结论:本研究构建的风险预测模型具有较好的预测效果,可为医疗专业人员预测老年患者髋关节置换术后不良后果风险提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Establishment and Verification of Risk Prediction Model for Adverse Outcomes After Hip Arthroplasty in Elderly Patients.

Background: Adverse outcomes after hip arthroplasty in elderly patients are frequently observed; however, most existing studies concentrate on single complications. Comprehensive predictive models for a wider range of adverse outcomes remain insufficient. This study explores this issue and proposes new approaches for clinical practice.

Purpose: This study aimed to construct and verify risk prediction model for adverse outcomes after hip arthroplasty in elderly patients.

Patients and methods: The TRIPOD checklist was followed to guide the reporting of this study. Data from 620 subjects who underwent hip arthroplasty at a tertiary A-level hospital from January 1, 2021 to December 31, 2023 were used for the modelling group. Additionally, 264 post-hip arthroplasty patients admitted to the orthopaedic department of another tertiary A-level hospital from January 1, 2024 to December 31, 2024 were selected as the validation group. Risk prediction models were constructed by logistic regression, plotted in column line graphs and evaluated for their predictive effectiveness.

Results: The factors included in the prediction model were age, malignancy history, surgical procedure, albumin, prothrombin time, ASA grade, operation duration, and changeover surgery status. Hosmer-Lemeshow test, χ2=5.418, p=0.712, the area under the receiver operating characteristic curve (AUC) was 0.902. The Youden index is 0.668, with a sensitivity of 0.84 and a specificity of 0.828. The correct practical application rate was 83.33%.

Conclusion: The risk prediction model constructed in this study demonstrates favourable predictive performance and can serve as a reference for healthcare professionals in predicting the risk of adverse outcomes after hip arthroplasty in elderly patients.

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来源期刊
Therapeutics and Clinical Risk Management
Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-
CiteScore
5.30
自引率
3.60%
发文量
139
审稿时长
16 weeks
期刊介绍: Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.
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