血浆类胡萝卜素与粒细胞计数和可溶性炎症标志物在中年人中呈负相关:一项具有中介分析的横断面研究。

IF 7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Jan Neelissen, Per Leanderson, Fredrik H Nyström, Lena Jonasson, Rosanna W S Chung
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引用次数: 0

摘要

背景:大量摄入水果和蔬菜通常与降低炎症水平有关。与此一致,血浆类胡萝卜素水平与炎症标志物呈负相关,特别是c反应蛋白(CRP)和白细胞计数。然而,目前尚不清楚类胡萝卜素与特定白细胞亚群或其他炎症标志物的关联程度。本研究系统地评估了中年人群中总类胡萝卜素和单个类胡萝卜素、循环白细胞亚群和可溶性炎症标志物之间的相互关系。方法:从瑞典心肺生物图像研究(SCAPIS)队列中招募了1078名年龄在50-64岁之间的受试者。全血流式细胞术测定白细胞亚群。测定血浆中叶黄素、β-隐黄素、番茄红素、α-胡萝卜素、β-胡萝卜素等5种主要类胡萝卜素,以及CRP、白细胞介素(IL)-6、白细胞介素-18、基质金属蛋白酶(MMP)-9、髓过氧化物酶(MPO)等炎症标志物。通过有效的食物频率问卷来估计营养摄入量。结果:在白细胞亚群中,只有粒细胞在调节后与所有类胡萝卜素呈独立和负相关。CRP、IL-18和MMP-9与大多数类胡萝卜素表现出类似的负相关关系。中介分析显示,类胡萝卜素与CRP和MMP-9的关联是由粒细胞计数介导的。在考虑到粒细胞计数的中介作用后,叶黄素和β-隐黄质仍然与MMP-9独立相关。没有估计的营养摄入量显示出与白细胞亚群或炎症标志物的可比关联。结论:据我们所知,这是调查血浆类胡萝卜素、白细胞亚群和可溶性炎症标志物之间关系的最大的基于人群的研究。它提供了血浆中低水平类胡萝卜素与低级别慢性炎症有关的证据,而且,这种关系是由粒细胞数量介导的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma carotenoids are inversely correlated with granulocyte counts and soluble inflammatory markers in a middle-aged population: a cross-sectional study with mediation analysis.

Background: High intake of fruits and vegetables is generally associated with reduced levels of inflammation. In line with this, plasma levels of carotenoids have shown inverse associations with inflammatory markers, in particular C-reactive protein (CRP) and leukocyte counts. However, it remains unclear to what extent carotenoids are associated with specific leukocyte subsets or other inflammatory markers. This study systematically assessed the inter-relationships among total and individual carotenoids, circulating leukocyte subsets, and soluble inflammatory markers in a middle-aged population.

Methods: A subcohort of 1078 subjects, aged 50-64, was recruited from the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort. Leukocyte subsets were determined by whole blood flow cytometry. Five major carotenoids, namely lutein, β-cryptoxanthin, lycopene, α-carotene and β-carotene, and inflammatory markers including CRP, interleukin (IL)-6 and interleukin-18, matrix metalloproteinase (MMP)-9, and myeloperoxidase (MPO), were measured in plasma. Nutrient intake was estimated by validated food frequency questionnaires.

Results: Among leukocyte subsets, only granulocytes showed independent and inverse associations with all carotenoids after adjustment. CRP, IL-18, and MMP-9 exhibited similar inverse relationships with most carotenoids. Mediation analysis revealed that the associations of carotenoids with CRP and MMP-9 were mediated by granulocyte counts. Lutein and β-cryptoxanthin remained independently associated with MMP-9 after accounting for the mediation effects of granulocyte counts. No estimated nutrient intake showed comparable associations with leukocyte subsets or inflammatory markers.

Conclusions: To our knowledge, this is the largest population-based study investigating relationships between plasma carotenoids, leukocyte subsets, and soluble inflammatory markers. It provides evidence that low levels of carotenoids in plasma are linked to low-grade chronic inflammation and, furthermore, that this relationship is mediated by granulocyte numbers.

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来源期刊
BMC Medicine
BMC Medicine 医学-医学:内科
CiteScore
13.10
自引率
1.10%
发文量
435
审稿时长
4-8 weeks
期刊介绍: BMC Medicine is an open access, transparent peer-reviewed general medical journal. It is the flagship journal of the BMC series and publishes outstanding and influential research in various areas including clinical practice, translational medicine, medical and health advances, public health, global health, policy, and general topics of interest to the biomedical and sociomedical professional communities. In addition to research articles, the journal also publishes stimulating debates, reviews, unique forum articles, and concise tutorials. All articles published in BMC Medicine are included in various databases such as Biological Abstracts, BIOSIS, CAS, Citebase, Current contents, DOAJ, Embase, MEDLINE, PubMed, Science Citation Index Expanded, OAIster, SCImago, Scopus, SOCOLAR, and Zetoc.
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